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ATP-Dependent Nucleosome Reconfiguration and Transcriptional Activation from Preassembled Chromatin Templates
Abstract
GAL4-VP16-mediated nucleosome reconfiguration and transcriptional activation were observed with preassembled chromatin templates that contained regular and physiological nucleosome spacing. Both processes were dependent on adenosine triphosphate (ATP), although binding of GAL4-VP16 to the chromatin was ATP-independent. Factor-mediated nucleosome reconfiguration was not, however, sufficient for transcriptional activation. These experiments recreate in vitro the active participation of nucleosomal cores in the regulation of transcription that occurs in vivo, and they suggest a multistep pathway for transcriptional activation in which factor- and ATP-dependent nucleosome reconfiguration is followed by facilitation by the DNA-bound activator of transcription from the repressed chromatin template.
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Citations
Cited by
Nucleosome Remodeling and Epigenetics
Becker, P. B., & Workman, J. L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017905 · Cited by 355
Mayall, T. P., Sheridan, P. L., Montminy, M. R., & Jones, K. A. (1997) · Genes & Development · doi:10.1101/gad.11.7.887 · Cited by 118
Mechanisms of transcription complex assembly
Pugh, B. F. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80002-0 · Cited by 87
Metadata
- Authors
- Pazin, M. J., Kamakaka, R. T., & Kadonaga, J. T.
- Venue
- Science
- Published
- 1994-12-23
- Volume
- 266
- Issue
- 5193
- Pages
- 2007-2011
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040621359
- Cited by
- 164
- References
- 0
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: ATP-Dependent Nucleosome Reconfiguration and Transcriptional Activation from Preassembled Chromatin Templates. https://app.cochat.ai/papers/10.1126/science.7801129
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- Pazin, M. J., Kamakaka, R. T., & Kadonaga, J. T. (1994). ATP-Dependent Nucleosome Reconfiguration and Transcriptional Activation from Preassembled Chromatin Templates. Science. https://doi.org/10.1126/science.7801129
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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