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Human Malaria Parasites in Continuous Culture
Abstract
Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38°C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen (1 or 5 percent). The original parasite material, derived from an infected Aotus trivirgatus monkey, was diluted more than 100 million times by the addition of human erythrocytes at 3- or 4-day intervals. The parasites continued to reproduce in their normal asexual cycle of approximately 48 hours but were no longer highly synchronous. They have remained infective to Aotus .
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Cited by
Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity
Ramirez, J. L., Garver, L. S., Brayner, F. A., Alves, L. C., Rodrigues, J., Molina-Cruz, A., & Barillas-Mury, C. (2014) · Journal of Innate Immunity · doi:10.1159/000353765 · Cited by 1,084
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
Wootton, J. C., Feng, X., Ferdig, M. T., Cooper, R. A., Mu, J., Baruch, D. I., Magill, A. J., & Su, X.-Z. (2002) · Nature · doi:10.1038/nature00813 · Cited by 722
Bull, P. C., Lowe, B. S., Kortok, M., Molyneux, C. S., Newbold, C. I., & Marsh, K. (1998) · Nature Medicine · doi:10.1038/nm0398-358 · Cited by 645
Rapid switching to multiple antigenic and adhesive phenotypes in malaria
Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619
Metadata
- Authors
- Trager, W., & Jensen, J. B.
- Venue
- Science
- Published
- 1976-08-20
- Volume
- 193
- Issue
- 4254
- Pages
- 673-675
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969503178
- Cited by
- 7,844
- References
- 0
- FWCI
- 65.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trager, W., & Jensen, J. B. (1976). Human Malaria Parasites in Continuous Culture. Science. https://doi.org/10.1126/science.781840
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
