Enhancer Point Mutation Results in a Homeotic Transformation in Drosophila
Abstract
In Drosophila , the misexpression or altered activity of genes from the bithorax complex results in homeotic transformations. One of these genes, abd-A , normally specifies the identity of the second through fourth abdominal segments (A2 to A4). In the dominant Hyperabdominal mutations ( Hab ), portions of the third thoracic segment (T3) are transformed toward A2 as the result of ectopic abd-A expression. Sequence analysis and deoxyribonuclease I footprinting demonstrate that the misexpression of abd-A in two independent Hab mutations results from the same single base change in a binding site for the gap gene Krüppel protein. These results establish that the spatial limits of the homeotic genes are directly regulated by gap gene products.
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In Drosophila, point mutations in the binding site for the Kruppel transcription factor within an enhancer controlling the abdominal fate specifier abd-A result in its misexpression in a thoracic segment, leading to its conversion to an abdominal one.
“In Drosophila, for example, point mutations in the binding site for the Kruppel TF within an enhancer controlling the abdominal fate specifier abd-A results in its misexpression in a thoracic segment, leading to its conversion to an abdominal one [194].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [194]
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Transcriptional enhancers and their communication with gene promoters
Ray-Jones, H., & Spivakov, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03903-w · Cited by 81 · see citing works
- Authors
- Shimell, M. J., Simon, J., Bender, W., & O'Connor, M. B.
- Affiliations
- Department of Molecular Biology and Biochemistry and Developmental Biology Center, University of California, Irvine, CA 92717, USA.
- University of Minnesota (US)
- Harvard University (US)
- Venue
- Science
- Published
- 1994-05-13
- Volume
- 264
- Issue
- 5161
- Pages
- 968-971
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966375200
- Cited by
- 94
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 2
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- homeotic transformation, bithorax complex, abdominal-A, gap genes, segment identity, ectopic expression, Drosophila
- MeSH terms
- Animals, Base Sequence, Binding Sites, DNA-Binding Proteins, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Homeobox, Molecular Sequence Data, Nuclear Proteins, Proteins, Regulatory Sequences, Nucleic Acid, Repressor Proteins, Transcription Factors, Genes, Insect, Point Mutation, Drosophila Proteins, Kruppel-Like Transcription Factors
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