The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Crystal Structure of LacI Member, PurR, Bound to DNA: Minor Groove Binding by α Helices
Abstract
The three-dimensional structure of a ternary complex of the purine repressor, PurR, bound to both its corepressor, hypoxanthine, and the 16-base pair purF operator site has been solved at 2.7 Å resolution by x-ray crystallography. The bipartite structure of PurR consists of an amino-terminal DNA-binding domain and a larger carboxyl-terminal corepressor binding and dimerization domain that is similar to that of the bacterial periplasmic binding proteins. The DNA-binding domain contains a helix-turn-helix motif that makes base-specific contacts in the major groove of the DNA. Base contacts are also made by residues of symmetry-related α helices, the "hinge" helices, which bind deeply in the minor groove. Critical to hinge helix-minor groove binding is the intercalation of the side chains of Leu 54 and its symmetry-related mate, Leu 54′ , into the central CpG-base pair step. These residues thereby act as "leucine levers" to pry open the minor groove and kink the purF operator by 45 degrees.
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Cites
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Cited by
Structural basis for DNA bending by the architectural transcription factor LEF-1
Love, J. J., Li, X., Case, D. A., Giese, K., Grosschedl, R., & Wright, P. E. (1995) · Nature · doi:10.1038/376791a0 · Cited by 573
Structural Basis of the Redox Switch in the OxyR Transcription Factor
Choi, H.-J., Kim, S.-J., Mukhopadhyay, P., Cho, S., Woo, J.-R., Storz, G., & Ryu, S.-E. (2001) · Cell · doi:10.1016/s0092-8674(01)00300-2 · Cited by 560
Kinetics of Protein-DNA Interaction: Facilitated Target Location in Sequence-Dependent Potential
Slutsky, M., & Mirny, L. A. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.050765 · Cited by 526
Reinisch, K. M., Chen, L., Verdine, G. L., & Lipscomb, W. N. (1995) · Cell · doi:10.1016/0092-8674(95)90060-8 · Cited by 366
Recognition of Specific DNA Sequences
Garvie, C. W., & Wolberger, C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00392-6 · Cited by 357
Metadata
- Authors
- Schumacher, M. A., Choi, K. Y., Zalkin, H., & Brennan, R. G.
- Venue
- Science
- Published
- 1994-11-04
- Volume
- 266
- Issue
- 5186
- Pages
- 763-770
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072920810
- Cited by
- 371
- References
- 1
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schumacher, M. A., Choi, K. Y., Zalkin, H., & Brennan, R. G. (1994). Crystal Structure of LacI Member, PurR, Bound to DNA: Minor Groove Binding by α Helices. Science. https://doi.org/10.1126/science.7973627
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
