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Spermine and Spermidine as Gating Molecules for Inward Rectifier K + Channels
Abstract
Inward rectifier K + channels pass prominent inward currents, while outward currents are largely blocked. The inward rectification is due to block by intracellular Mg 2+ and a Mg 2+ -independent process described as intrinsic gating. The rapid loss of gating upon patch excision suggests that cytoplasmic factors participate in gating. "Intrinsic" gating can be restored in excised patches by nanomolar concentrations of two naturally occurring polyamines, spermine and spermidine. Spermine and spermidine may function as physiological blockers of inward rectifier K + channels and "intrinsic" gating may largely reflect voltage-dependent block by these cations.
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Cited by
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Toward Understanding the Assembly and Structure of KATPChannels
AGUILAR-BRYAN, L., CLEMENT, J. P., GONZALEZ, G., KUNJILWAR, K., BABENKO, A., & BRYAN, J. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.227 · Cited by 540
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem
Ketchum, K. A., Joiner, W. J., Sellers, A. J., Kaczmarek, L. K., & Goldstein, S. A. N. (1995) · Nature · doi:10.1038/376690a0 · Cited by 438
Knot, H. J., Zimmermann, P. A., & Nelson, M. T. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021318 · Cited by 331
Metadata
- Authors
- Ficker, E., Taglialatela, M., Wible, B. A., Henley, C. M., & Brown, A. M.
- Venue
- Science
- Published
- 1994-11-11
- Volume
- 266
- Issue
- 5187
- Pages
- 1068-1072
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044813037
- Cited by
- 522
- References
- 0
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ficker, E., Taglialatela, M., Wible, B. A., Henley, C. M., & Brown, A. M. (1994). Spermine and Spermidine as Gating Molecules for Inward Rectifier K + Channels. Science. https://doi.org/10.1126/science.7973666
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
