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Growth-Promoting Effects of Glycine-Extended Progastrin
Abstract
Peptide α amidation is required to produce some hormones, such as gastrin, from their glycine-extended precursors. This terminal posttranslational processing reaction is thought to be essential for the biological activation of many peptide hormones; only amidated gastrin exerts a physiological effect that results in gastric acid secretion. However, both amidated gastrin and glycine-extended gastrin stimulate proliferation of exocrine pancreatic cell line AR4-2J through selective receptors for the substrate and the product, respectively, of peptide α amidation. Thus, the amidation reaction may function as a determinant of the specific biological actions of products derived from prohormones.
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Cited by
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Haber, S. N. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.003 · Cited by 1,479
Cholecystokinin and Gastrin Receptors
Dufresne, M., Seva, C., & Fourmy, D. (2006) · Physiological Reviews · doi:10.1152/physrev.00014.2005 · Cited by 476
Self-citationThe New Biology of Gastrointestinal Hormones
REHFELD, J. F. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1087 · Cited by 329
Processing and proliferative effects of human progastrin in transgenic mice.
Wang, T. C., Koh, T. J., Varro, A., Cahill, R. J., Dangler, C. A., Fox, J. G., & Dockray, G. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118993 · Cited by 300
Chronic Proton Pump Inhibitor Therapy and the Risk of Colorectal Cancer
Yang, Y., Hennessy, S., Propert, K., Hwang, W., Sedarat, A., & Lewis, J. D. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.022 · Cited by 125
Metadata
- Authors
- Seva, C., Dickinson, C. J., & Yamada, T.
- Venue
- Science
- Published
- 1994-07-15
- Volume
- 265
- Issue
- 5170
- Pages
- 410-412
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994672525
- Cited by
- 334
- References
- 0
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seva, C., Dickinson, C. J., & Yamada, T. (1994). Growth-Promoting Effects of Glycine-Extended Progastrin. Science. https://doi.org/10.1126/science.8023165
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