A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Oncogenes and signal transduction

Cantley, L. C., Auger, K. R., Carpenter, C. F., Duckworth, B. C., Graziani, A., Kapeller, R., & Soltoff, S. P. (1991) · Cell · doi:10.1016/0092-8674(91)90639-g · Cited by 2,697

Growth Factors and Cancer

Aaronson, S. A. (1991) · Science · doi:10.1126/science.1659742 · Cited by 2,017

Growth factor signaling by receptor tyrosine kinases

Schlessinger, J., & Ullrich, A. (1992) · Neuron · doi:10.1016/0896-6273(92)90177-f · Cited by 1,418

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

Carpenter, G. F. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.004313 · Cited by 1,282

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

Morrison, J. F. (1969) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(69)90420-3 · Cited by 815

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

Sandgren, E. P., Luetteke, N., Palmiter, R. D., Brinster, R. L., & Lee, D. C. (1990) · Cell · doi:10.1016/0092-8674(90)90075-p · Cited by 752

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., & Merlino, G. T. (1990) · Cell · doi:10.1016/0092-8674(90)90076-q · Cited by 709

DIOGENES SYNDROME

Clark, A. N. G., Mankikar, G. D., & Gray, I. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91280-5 · Cited by 697

EPIDERMAL-GROWTH-FACTOR RECEPTORS IN HUMAN BLADDER CANCER: COMPARISON OF INVASIVE AND SUPERFICIAL TUMOURS

Neal, D. E., Bennett, M., Hall, R. R., Marsh, C., Abel, P., Sainsbury, J. R. C., & Harris, A. L. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91386-8 · Cited by 604

Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies

Masui, H., Kawamoto, T., Sato, J., Wolf, B., SATO, G. H., & Mendelsohn, J. M. (1984) · The Journal of Urology · doi:10.1016/s0022-5347(17)50005-1 · Cited by 446

Receptor Type Protein Tyrosine Phosphatase-Kappa Mediates Cross-Talk between Transforming Growth Factor-Beta and Epidermal Growth Factor Receptor Signaling Pathways in Human Keratinocytes

Xu, Y., Baker, D. K., Quan, T., Baldassare, J. J., Voorhees, J. J., & Fisher, G. J. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-08-0710 · Cited by 27

Organocatalytic Visible Light Enabled SNAr of Heterocyclic Thiols: A Metal-Free Approach to 2-Aminobenzoxazoles and 4-Aminoquinazolines

Rattanangkool, E., Sukwattanasinitt, M., & Wacharasindhu, S. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b02357 · Cited by 27

LymnaeaEpidermal Growth Factor Promotes Axonal Regeneration in CNS Organ Culture

Wildering, W. C., Hermann, P. M., & Bulloch, A. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09345.2001 · Cited by 27

Heterogeneity of signal transduction at the subcellular level: microsphere-based focal EGF receptor activation and stimulation of Shc translocation

Brock, R. E., & Jovin, T. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2437 · Cited by 27

Epidermal Growth Factor Receptor Phosphorylates Protein Kinase C at Tyr332 to form a Trimeric Complex with p66Shc in the H2O2-stimulated Cells

Morita, M., Matsuzaki, H., Yamamoto, T., Fukami, Y., & Kikkawa, U. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvm190 · Cited by 27

Role of EGFR Transactivation in Angiotensin II Signaling to Extracellular Regulated Kinase in Preglomerular Smooth Muscle Cells

Andresen, B. T., Linnoila, J., Jackson, E. K., & Romero, G. G. (2003) · Hypertension · doi:10.1161/01.hyp.0000049426.61176.df · Cited by 27

Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma

Tanaka, S., Sugimachi, K., Kawaguchi, H., Saeki, H., Ohno, S., Wands, J. R., & Sugimachi, K. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200006)183:3 · Cited by 55

Leptin in relation to prostate cancer and benign prostatic hyperplasia

Λάγιου, Π., Signorello, L. B., Trichopoulos, D., Τζώνου, Α., Trichopoulou, A., & Mantzoros, C. S. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980330)76:1 · Cited by 76

Clinical use of tyrosine kinase inhibitors: therapy for chronic myelogenous leukemia and other cancers.

Donato, N. J., & Talpaz, M. (2000) · PubMed · Cited by 27

Synthesis and biological evaluation of novel quinazoline-sulfonamides as anti-cancer agents

Poudapally, S., Battu, S., Velatooru, L. R., Bethu, M. S., Janapala, V. R., Sharma, S., Sen, S., Pottabathini, N., Iska, V. B. R., & Katangoor, V. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.03.042 · Cited by 26

An Efficient Three‐component, One‐pot Synthesis of Quinazolines under Solvent‐free and Catalyst‐free Condition

Bhat, S. I., Das, U. K., & Trivedi, D. R. (2014) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.2220 · Cited by 26

Benzamides and benzamidines as specific inhibitors of epidermal growth factor receptor and v-Src protein tyrosine kinases

Asano, T., Yoshikawa, T., Usui, T., Yamamoto, H., Yamamoto, Y., Uehara, Y., & Nakamura, H. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.04.030 · Cited by 28

TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

Valente, P., Fassina, G., Melchiori, A., Masiello, L., Cilli, M., Vacca, A., Onisto, M., Santi, L., Stetler‐Stevenson, W. G., & Albini, A. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980119)75:2 · Cited by 272

Tyrphostins That Suppress the Growth of Human Papilloma Virus 16-Immortalized Human Keratinocytes

Ben‐Bassat, H., Rosenbaum-Mitrani, S., Hartzstark, Z., Levitzki, R., Chaouat, M., Shlomai, Z., Klein, B., Kleinberger-Doron, N., Gazit, A., Tsvieli, R., et al. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35052-9 · Cited by 26

Inhibition of Growth Factor-Mediated Tyrosine Phosphorylation in Vascular Smooth Muscle by PD 089828, a New Synthetic Protein Tyrosine Kinase Inhibitor

Dahring, T. K., Lu, G. H., Hamby, J. M., Batley, B. L., Kraker, A. J., & Panek, R. L. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36726-6 · Cited by 26

Discovering novel 3-nitroquinolines as a new class of anticancer agents

Li, H., Huang, H., Zhang, X., Luo, X., Lin, L., Jiang, H., Ding, J., Chen, K., & Liu, H. S. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00907.x · Cited by 25

The reduced osteogenic potential of Nf1-deficient osteoprogenitors is EGFR-independent

Tahaei, S. M. E., Couasnay, G., Ma, Y., Paria, N., Gu, J., Lemoine, B., Wang, X., Rios, J. J., & Elefteriou, F. (2017) · Bone · doi:10.1016/j.bone.2017.10.012 · Cited by 25

The combi-targeting concept: intracellular fragmentation of the binary epidermal growth factor (EGFR)/DNA targeting “combi-triazene” SMA41

Matheson, S. L., Brahimi, F., & Jean‐Claude, B. J. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.10.035 · Cited by 25

Epidermal growth factor receptor‐dependent PI3K‐activation promotes restitution of wounded human gastric epithelial monolayers

Tétreault, M., Chailler, P., Beaulieu, J., Rivard, N., & Ménard, D. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21239 · Cited by 25

Reactive Oxygen Species as Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation in Keratinocytes

Péus, D., & Pittelkow, M. R. (2000) · KARGER eBooks · doi:10.1159/000060661 · Cited by 25

Inhibition of fast sodium current in rabbit ventricular myocytes by protein tyrosine kinase inhibitors

Wang, Y., Wagner, M. B., Kumar, R., Cheng, J., & Joyner, R. W. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1061-8 · Cited by 25

Enantioselective inhibition of the epidermal growth factor receptor tyrosine kinase by 4-(α-phenethylamino)quinazolines

Bridges, A. J., Cody, D. R., Zhou, H., McMichael, A., & Fry, D. W. (1995) · Bioorganic & Medicinal Chemistry · doi:10.1016/0968-0896(95)00149-2 · Cited by 25

DNA Interaction of the Tyrosine Protein Kinase Inhibitor PD153035 and Its N-Methyl Analogue

Goossens, J., Bouey-Bencteux, E., Houssin, R., Hénichart, J., Colson, P., Houssier, C., Laine, W., Baldeyrou, B., & Bailly, C. (2001) · Biochemistry · doi:10.1021/bi002777a · Cited by 25

Patent Update: Oncologic, Endocrine & Metabolic Small molecule inhibitors of tyrosine kinase activity

Spada, A. P., & Myers, M. R. (1995) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.5.8.805 · Cited by 25

Inhibitors of protein tyrosine kinases

Fry, D. W., & Bridges, A. J. (1995) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(95)80109-x · Cited by 25

Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function

Lahey, K., Ronaghan, N. J., Shang, J., Dion, S. P., Désilets, A., Leduc, R., & MacNaughton, W. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180259 · Cited by 24

Design, synthesis and molecular docking studies of quinazolin-4-ones linked to 1,2,3-triazol hybrids as Mycobacterium tuberculosis H37Rv inhibitors besides antimicrobial activity

Maddali, N. K., Viswanath, I. V. K., Murthy, Y. L. N., Bera, R., Takhi, M., Rao, N. S., & Gudla, V. (2019) · Medicinal Chemistry Research · doi:10.1007/s00044-019-02313-9 · Cited by 24

Synthesis and anticancer activities of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline derivatives

Zhang, Y., Jin, L., Xiang, H., Wu, J. P., Wang, P., Hu, D., Xue, W., & Yang, S. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.05.043 · Cited by 24

Targeting Epidermal Growth Factor Receptor with Ferrocene-Based Kinase Inhibitors

Amin, J., Chuckowree, I., Tizzard, G. J., Coles, S. J., Wang, M., Bingham, J. P., Hartley, J. A., & Spencer, J. (2013) · Organometallics · doi:10.1021/om300974d · Cited by 24

Synthesis and Evaluation of Novel [1,2,4]Triazolo[1,5‐c]quinazoline Derivatives as Antibacterial Agents

Zeydi, M. M., Montazeri, N., & Fouladi, M. (2017) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.2979 · Cited by 24

EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration

Sturz, A., Bader, B., Thierauch, K., & Glienke, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.092 · Cited by 24

Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases

Zaman, G. J. R., Vink, P. M., van der Doelen, A. A., Veeneman, G. H., & Theunissen, H. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00271-8 · Cited by 24

Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium

Uesaka, T., Lu, H., Katoh, O., & Watanabe, H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00075.2002 · Cited by 24

Inhibition of growth of primary human tumour cell cultures by a 4-anilinoquinazoline inhibitor of the epidermal growth factor receptor family of tyrosine kinases

Baguley, B. C., Marshall, E. S., Holdaway, K. M., Rewcastle, G. W., & Denny, W. A. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00043-4 · Cited by 24

Synthetic approaches and potential bioactivity of different functionalized quinazoline and quinazolinone scaffolds

Anwar, M., Kamel, M., Zaghary, W. A., & Al-Wabli, R. I. (2016) · Egyptian Pharmaceutical Journal · doi:10.4103/1687-4315.197580 · Cited by 23

Framework Copper Catalyzed Oxidative Synthesis of Quinazolinones: A Benign Approach Using Cu 3 (BTC) 2 MOF as an Efficient and Reusable Catalyst

Latha, G., Devarajan, N., & Suresh, P. (2020) · ChemistrySelect · doi:10.1002/slct.202002661 · Cited by 23

Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp3)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium

Zhou, Z., Hu, K., Wang, J., Li, Z., Zhang, Y., Zha, Z., & Wang, Z. (2020) · ACS Omega · doi:10.1021/acsomega.0c04865 · Cited by 23

Computationally repurposing drugs for breast cancer subtypes using a network-based approach

Firoozbakht, F., Rezaeian, I., Rueda, L. G., & Ngom, A. (2022) · BMC Bioinformatics · doi:10.1186/s12859-022-04662-6 · Cited by 24

INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR

Batley, B. L., Doherty, A. M., Hamby, J. M., Lu, G. H., Keller, P., Dahring, T. K., Hwang, O., Crickard, K., & Panek, R. L. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)01060-6 · Cited by 23

Yeast Growth Selection System for Detecting Activity and Inhibition of Dimerization-Dependent Receptor Tyrosine Kinase

Gunde, T., & Barberis, A. (2005) · BioTechniques · doi:10.2144/000112011 · Cited by 23

Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells

Sakanyan, V. A., Angelini, M., Béchec, M. L., Lecocq, M., Benaiteau, F., Rousseau, B., Gyulkhandanyan, A., Gyulkhandanyan, L., Logé, C., Reiter, É., et al. (2014) · Scientific Reports · doi:10.1038/srep03977 · Cited by 23

FIP-2, an IκB-Kinase-γ-Related Protein, Is Associated with the Golgi Apparatus and Translocates to the Marginal Band during Chicken Erythroblast Differentiation

Stroissnigg, H. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5567 · Cited by 23

Assessment of Cancer‐Associated Biomarkers by Positron Emission Tomography: Advances and Challenges

Collier, T. L., Lecomte, R., McCarthy, T. J., Meikle, S. R., Ruth, T. J., Scopinaro, F., Signore, A., Brocklin, H. V., de Wiele, C. V., & Waterhouse, R. N. (2002) · Disease Markers · doi:10.1155/2002/879647 · Cited by 23

Inhibitors of HER2/neu (erbB-2) signal transduction

Arteaga, C. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90106-x · Cited by 23

Synthesis and structure–activity relationship for new series of 4-Phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase

Kubo, K., Ohyama, S.-I., Shimizu, T., Takami, A., Murooka, H., Nishitoba, T., Kato, S., Yagi, M., Kobayashi, Y., Iinuma, N., et al. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2003.08.020 · Cited by 22

Suppression of Heregulin β Signaling by the Single N-Glycan Deletion Mutant of Soluble ErbB3 Protein

Takahashi, M., Hasegawa, Y., Ikeda, Y., Wada, Y., Tajiri, M., Ariki, S., Takamiya, R., Nishitani, C., Araki, M., Yamaguchi, Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.491902 · Cited by 22

A convenient synthesis of quinazoline derivatives via cascade imino-Diels-Alder and oxidation reaction

Chen, X. M., Hui, W., Yin, L., & Li, X. S. (2010) · Chinese Chemical Letters · doi:10.1016/j.cclet.2010.03.003 · Cited by 22

Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes

Vasdev, N., Dorff, P. N., O’Neil, J. P., Chin, F. T., Hanrahan, S. M., & VanBrocklin, H. F. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.03.032 · Cited by 22

Determining the binding mode and binding affinity constant of tyrosine kinase inhibitor PD153035 to DNA using optical tweezers

Cheng, C., Lee, Y., Wang, W., Hsu, C.-T., Tsai, J.-S., Wu, C.-M., Ou, K., & Yang, T. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.110 · Cited by 22

Epidermal growth factor receptor inhibitors: a patent review (2010 – present)

Li, S., & Li, H. (2014) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2014.871527 · Cited by 22

Comparison of Elisa-Based Tyrosine Kinase Assays for Screening EGFR Inhibitors

Várkondi, E., Schäfer, E., Bökönyi, G., Gyokeres, T., Őrfi, L., Peták, I., Pap, Á., Szokolóczi, O., Kéri, G., & Schwab, R. E. (2005) · Journal of Receptors and Signal Transduction · doi:10.1081/rrs-200055095 · Cited by 22

Reconstitution of Amphiregulin–Epidermal Growth Factor Receptor Signaling in Lung Squamous Cell Carcinomas Activates PTHrP Gene Expression and Contributes to Cancer-Mediated Diseases of the Bone

Gilmore, J. L., Gonterman, R. M., Menon, K., Lorch, G., Riese, D. J., Robling, A. G., & Foley, J. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0131 · Cited by 22

In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022

McLeod, H., Brunton, V., Eckardt, N., Lear, M. J., Robins, D., Workman, P., & Graham, M. A. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.620 · Cited by 22

Epidermal growth factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1β

Yucel‐Lindberg, T., & Brunius, G. (2006) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2006.03.004 · Cited by 21

An Expeditious Green Cascade Synthesis of 3‐Arylideneaminoquinazolin‐4(1 H )‐one Derivatives via ‘Solvent Drop Grinding’ and Their Antioxidant and DNA Protective Studies

Kuntikana, S., Bhat, C., Kongot, M., Bhat, S. I., & Kumar, A. (2016) · ChemistrySelect · doi:10.1002/slct.201600362 · Cited by 21

Discovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors

Sun, J., Wang, X.-Y., Lv, P., & Zhu, H. (2015) · Scientific Reports · doi:10.1038/srep13934 · Cited by 21

Benzodiazepine Compounds as Inhibitors of the Src Protein Tyrosine Kinase: Screening of a Combinatorial Library of 1,4-Benzodiazepines

Ramdas, L., Bunin, B. A., Plunkett, M. J., Sun, G., Ellman, J. A., Gallick, G. E., & Budde, R. J. A. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1313 · Cited by 21

A convenient synthesis of 5‐ and 8‐nitroquinazoline‐2,4‐dione derivatives

Aziane, D., Soukri, M., Hakmaoui, A. E., Lazar, S., Mohamed Akssira, A., Essassi, E. M., & Guillaumet, G. (2002) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.5570390204 · Cited by 21

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

Ebied, M., Zaghary, W. A., Amin, K., & Hammad, S. (2017) · Journal of Advanced Pharmacy Research · doi:10.21608/aprh.2017.4043 · Cited by 20

Benzofuran–appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies

Mphahlele, M. J., Maluleka, M. M., Aro, A. O., McGaw, L. J., & Choong, Y. S. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1510919 · Cited by 20

Intracellular Delivery of Drugs to Macrophages

Mukhopadhyay, A., & Basu, S. K. (2003) · Advances in biochemical engineering, biotechnology · doi:10.1007/3-540-36488-9_6 · Cited by 20

An EGF receptor inhibitor induces RAR-β expression in breast and ovarian cancer cells

Grunt, T. W., Puckmair, K., Tomek, K., Kainz, B., & Gaiger, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.104 · Cited by 20

Selective inhibition of EGFR and VEGFR2 tyrosine kinases controlled by a boronic acid substituent on 4-anilinoquinazolines

Nakamura, H., Horikoshi, R., Usui, T., & Ban, H. S. (2010) · MedChemComm · doi:10.1039/c0md00115e · Cited by 20

ErbB receptor tyrosine kinase inhibitors as therapeutic agents

Anderson, N. G. (2002) · Frontiers in bioscience · doi:10.2741/a889 · Cited by 25

Transformation of 5,5-diaryl-4,5-dihydro-1,2,4-oxadiazoles to 4-arylquinazolines

Szczepankiewicz, W., Wagner, P., Danicki, M., & Suwiński, J. (2003) · Tetrahedron Letters · doi:10.1016/s0040-4039(03)00229-6 · Cited by 20

Conformation‐dependent intermolecular interaction energies of the triphosphate anion with divalent metal cations. Application to the ATP‐binding site of a binuclear bacterial enzyme. A parallel quantum chemical and polarizable molecular mechanics investigation

Gresh, N., & Shi, G. (2003) · Journal of Computational Chemistry · doi:10.1002/jcc.10312 · Cited by 20

Epidermal growth factor‐dependent enhancement of axonal regeneration in the pond snail Lymnaea stagnalis: Role of phagocyte survival

Hermann, P. M., Nicol, J. J., Nagle, G. T., Bulloch, A. G. M., & Wildering, W. C. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20732 · Cited by 20

Synthesis and biological evaluation of allenic quinazolines using palladium-catalyzed hydride-transfer reaction

Nakamura, H., & Onagi, S. (2006) · Tetrahedron Letters · doi:10.1016/j.tetlet.2006.02.043 · Cited by 20

EGF Family Receptors and Their Ligands in Human Cancer

Tang, C. K., & Lippman, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012312411-1/50006-8 · Cited by 20

Inhibition of cell signalling pathways

Langdon, S. P. (1995) · Cancer Treatment Reviews · doi:10.1016/0305-7372(95)90011-x · Cited by 20

Editorial Oncologic, Endocrine & Metabolic: The current status of tyrosine kinase inhibitors: Do the diarylamine inhibitors of the EGF receptor represent a new beginning?

Bridges, A. J. (1995) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.5.12.1245 · Cited by 20

Recent advances in the design of small molecular drugs with acrylamides covalent warheads

Liang, L., Zhang, Z., You, Q., & Guo, X. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117902 · Cited by 20

Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity

Xu, Y., Li, S., Yu, G.-J., Hu, Q., & Li, H. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.06.070 · Cited by 19

Electrochemical oxidative decarboxylative of α-oxocarboxylic acids towards the synthesis of quinazolines and quinazolinones

Wu, J., Zhang, M., He, J. H., Li, K., Ye, L., Zhou, J., Xu, X., Li, Z., & Xu, H. (2024) · RSC Advances · doi:10.1039/d4ra01318b · Cited by 19

Heterocondensed quinazolones: synthesis and protein-tyrosine kinase inhibitory activity of 3,4-dihydro-1H,6H-[1,4]oxazino-[3,4-b]quinazolin-6-one derivatives

Őrfi, L., Kökösi, J., Szász, G., Kövesdi, I., Mák, M., Teplán, I., & Kéri, G. (1996) · Bioorganic & Medicinal Chemistry · doi:10.1016/0968-0896(96)00040-5 · Cited by 19

Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor

Bhattacharya, S. K., Cox, E. D., Kath, J. C., Mathiowetz, A. M., Morris, J., Moyer, J. D., Pustilnik, L. R., Rafidi, K., Richter, D. T., Su, C., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01160-4 · Cited by 19

ErbB receptor tyrosine kinase inhibitors as therapeutic agents

Neil, G. A. (2002) · Frontiers in bioscience · doi:10.2741/anderson · Cited by 19

From Consensus Sequence Peptide to High Affinity Ligand, a “Library Scan” Strategy

Yeh, R.-H., Lee, T. R., & Lawrence, D. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011232200 · Cited by 19

Thyrotropin-Releasing Hormone Stimulates Phosphorylation of the Epidermal Growth Factor Receptor in GH3 Pituitary Cells

Wang, Y.-H., Jue, S. F., & Maurer, R. A. (2000) · Molecular Endocrinology · doi:10.1210/me.14.9.1328 · Cited by 19

Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor

Harper, M. E., Goddard, L., Glynne-Jones, E., Assender, J. W., Dutkowski, C. M., Barrow, D., Dewhurst, O. L., Wakeling, A. E., & Nicholson, R. I. (2002) · The Prostate · doi:10.1002/pros.10069 · Cited by 19

Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to β-adrenergic G-protein-coupled receptor activation

Slomiany, B. L., & Slomiany, A. (2004) · Inflammopharmacology · doi:10.1163/1568560042342329 · Cited by 19

THE WILLET F. WHITMORE, JR., LECTURESHIP: BLOCKADE OF EPIDERMAL GROWTH FACTOR RECEPTORS AS ANTICANCER THERAPY

Mendelsohn, J. M., & Dinney, C. P. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)66453-1 · Cited by 19

Role of tyrosine kinases in lymphocyte activation: Targets for drug intervention

Hanke, J. H., Pollok, B. A., & Changelian, P. S. (1995) · Inflammation Research · doi:10.1007/bf01797862 · Cited by 19

Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3

Nowak, W., Parameswaran, N., Hall, C. S., Aiyar, N. V., SPARKS, H. V., & Spielman, W. S. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00561.2001 · Cited by 19

A Copper-Catalyzed Synthesis of Functionalized Quinazolines from Isocyanides and Aniline Tri- and Dichloroacetonitrile Adducts through Intramolecular C–H Activation

Tabatabai, S. A., Nematpour, M., Rezaee, E., & Jahani, M. (2017) · Synlett · doi:10.1055/s-0036-15588166 · Cited by 18

MATRIX METALLOPROTEINASE-7 AND EPIDERMAL GROWTH FACTOR RECEPTOR MEDIATE HYPOXIA-INDUCED EXTRACELLULAR SIGNAL-REGULATED KINASE 1/2 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION AND SUBSEQUENT PROLIFERATION IN BLADDER SMOOTH MUSCLE CELLS

SABHA, N., AITKEN, K. J., Lorenzo, A. J., Szybowska, M., Jairath, A., & Bägli, D. (2006) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/0510070.1 · Cited by 18

The combination of 4-anilinoquinazoline and cinnamic acid: A novel mode of binding to the epidermal growth factor receptor tyrosine kinase

Li, D., Lv, P., Zhang, H., Zhang, H., Hou, Y.-P., Liu, K., Ye, Y., & Zhu, H. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.06.044 · Cited by 18

FT‐IR and FT‐Raman spectra and ab initio calculations of 3‐{[(2‐hydroxyphenyl) methylene]amino}‐2‐phenylquinazolin‐4(3H)‐one

Panicker, C. Y., Varghese, H. T., Ambujakshan, K. R., Mathew, S., Ganguli, S., Nanda, A. K., & Alsenoy, C. V. (2009) · Journal of Raman Spectroscopy · doi:10.1002/jrs.2276 · Cited by 18

Postsynaptic expression of an epidermal growth factor receptor regulates cholinergic synapse formation between identified molluscan neurons

van Kesteren, R. E., Gagatek, J. S., Hagendorf, A., Gouwenberg, Y., Smit, A. B., & Syed, N. I. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06189.x · Cited by 18

The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing

Miura, Y., Bich, V. N. T., Furuya, M. H., Hasegawa, H., Takahashi, S., Katagiri, N., Hongu, T., Funakoshi, Y., Ohbayashi, N., & Kanaho, Y. (2017) · Scientific Reports · doi:10.1038/srep46649 · Cited by 18

Copper-mediated aerobic oxidative synthesis of benzimidazo fused quinazolines via a multicomponent approach

Rai, B., Kumar, P., & Kumar, A. (2015) · RSC Advances · doi:10.1039/c5ra15525h · Cited by 18

Regulation of Mesangial Cell Hexokinase Activity and Expression by Heparin-binding Epidermal Growth Factor-like Growth Factor

Robey, R. B., Ma, J., Santos, A. V. P., Noboa, O. A., Coy, P. E., & Bryson, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111722200 · Cited by 18

Antipsoriatic drug anthralin induces EGF receptor phosphorylation in keratinocytes: requirement for H2O2 generation

Péus, D., Beyerle, A., Vasa‐Nicotera, M., Pott, M., Meves, A., & Pittelkow, M. R. (2004) · Experimental Dermatology · doi:10.1111/j.0906-6705.2004.00119.x · Cited by 18

A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation

Kubo, K., Shimizu, T., Ohyama, S.-I., Murooka, H., Nishitoba, T., Kato, S., Kobayashi, Y., Yagi, M., Isoe, T., Nakamura, K., et al. (1997) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(97)10117-2 · Cited by 18

Tyrosine kinase signaling pathways control the expression of retinoic acid receptor-α in SK-BR-3 breast cancer cells

Flicker, S., Schneider, S. M., Offterdinger, M., Dittrich, E., Fazeny, B., Valenta, R., Huber, H. P., Dittrich, C., & Grunt, T. W. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04715-0 · Cited by 18

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

Popović, L., Wintgens, J. P., Wu, Y., Brankatschk, B., Menninger, S., Degenhart, C., Jensen, N., Wichert, S. P., Klebl, B., Rossner, M. J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108839 · Cited by 17

Vibrational spectroscopic (FT-IR and FT-Raman) studies, HOMO–LUMO, NBO analysis and MEP of 6-methyl-1-({[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl]oxy}methyl)-1,2,3,4-tetra-hydroquinazoline-2,4-dione, a potential chemotherapeutic agent, using density functional methods

Sebastian, S. S. H. R., Al-Tamimi, A.-M. S., El‐Brollosy, N. R., El-Emam, A. A.-R., Panicker, C. Y., & Alsenoy, C. V. (2014) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2014.06.039 · Cited by 17

Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase

Zhu, Z.-W., Shi, L., Ruan, X.-M., Yang, Y., Li, H., Xu, S., & Zhu, H. (2010) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756361003671060 · Cited by 17

A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity

Primas, N., Verhaeghe, P., Cohen, A., Kieffer, C., Dumètre, A., Hutter, S., Rault, S., Rathelot, P., Azas, N., & Vanelle, P. (2012) · Molecules · doi:10.3390/molecules17078105 · Cited by 17

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Li, H., Zhang, X., Tan, J., Chen, L., Liu, H., Luo, X., Shen, X., Lin, L., Chen, K., Ding, J., et al. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00473.x · Cited by 17

PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.

Bos, M., Mendelsohn, J. M., Kim, Y. M., Albanell, J., Fry, D. W., & Baselga, J. M. (1997) · PubMed · Cited by 199

Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice

Kunkel, M. W., Hook, K. E., Howard, C. T., Przybranowski, S. A., Roberts, B. J., Elliott, W. L., & Leopold, W. R. (1995) · Investigational New Drugs · doi:10.1007/bf00873135 · Cited by 59

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Rae, J. M., & Lippman, M. E. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000010702.10130.29 · Cited by 29

Cytoskeletal and Morphological Changes Associated with the Specific Suppression of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity in A431 Human Epidermoid Carcinoma

Nelson, J. M., & Fry, D. W. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3571 · Cited by 17

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Fry, D. W., Nelson, J. M., Slintak, V., Keller, P. R., Rewcastle, G. W., Denny, W. A., Zhou, H., & Bridges, A. J. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00242-6 · Cited by 65