The DOI matches its Crossref record.
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
Abstract
The radiosensitive mutant xrs-6, derived from Chinese hamster ovary cells, is defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. The human XRCC5 DNA repair gene, which complements this mutant, is shown here through genetic and biochemical evidence to be the 80-kilodalton subunit of the Ku protein. Ku binds to free double-stranded DNA ends and is the DNA-binding component of the DNA-dependent protein kinase. Thus, the Ku protein is involved in DNA repair and in V(D)J recombination, and these results may also indicate a role for the Ku-DNA-dependent protein kinase complex in those same processes.
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Cited by
Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi‐Iwai, Y., Shinohara, A., & Takeda, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5497 · Cited by 1,229
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells
Cuevas-Ramos, G., Petit, C. R., Marcq, I., Boury, M., Oswald, E., & Nougayrède, J.-P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001261107 · Cited by 855
DNA repair mechanisms in dividing and non-dividing cells
Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697
Moore, J. K., & Haber, J. E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2164 · Cited by 623
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
Critchlow, S. E., Bowater, R. P., & Jackson, S. P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00258-2 · Cited by 470
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Metadata
- Authors
- Taccioli, G., Gottlieb, T., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A., Alt, F., Jackson, S., & Jeggo, P.
- Venue
- Science
- Published
- 1994-09-02
- Volume
- 265
- Issue
- 5177
- Pages
- 1442-1445
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034353458
- Cited by
- 638
- References
- 0
- FWCI
- 26.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taccioli, G., Gottlieb, T., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A., Alt, F., Jackson, S., & Jeggo, P. (1994). Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science. https://doi.org/10.1126/science.8073286
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