The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver
Abstract
Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens.
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Citations
Cites
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Cited by
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Marnett, L. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.361 · Cited by 1,883
Self-citationLipid peroxidation—DNA damage by malondialdehyde
Marnett, L. J. (1999) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00010-x · Cited by 1,304
Self-citationOxy radicals, lipid peroxidation and DNA damage
Marnett, L. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00448-1 · Cited by 560
Self-citationRepair of DNA interstrand cross-links
Dronkert, M. L. G., & Kanaar, R. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00092-1 · Cited by 555
Metadata
- Authors
- Chaudhary, A. K., Nokubo, M., Reddy, G. R., Yeola, S. N., Morrow, J. D., Blair, L. A., & Marnett, L. J.
- Venue
- Science
- Published
- 1994-09-09
- Volume
- 265
- Issue
- 5178
- Pages
- 1580-1582
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965796676
- Cited by
- 374
- References
- 1
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chaudhary, A. K., Nokubo, M., Reddy, G. R., Yeola, S. N., Morrow, J. D., Blair, L. A., & Marnett, L. J. (1994). Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver. Science. https://doi.org/10.1126/science.8079172
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
