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Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor
Abstract
The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT 1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT 1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT 1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT 1B receptors in aggressive behavior.
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Citations
Cited by
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Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-09-05879.1995 · Cited by 1,138
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020
Neural mechanisms of aggression
Nelson, R. J., & Trainor, B. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2174 · Cited by 1,019
Metadata
- Authors
- Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., Buhot, M.-C., & Hen, R.
- Venue
- Science
- Published
- 1994-09-23
- Volume
- 265
- Issue
- 5180
- Pages
- 1875-1878
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076475195
- Cited by
- 845
- References
- 0
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., Buhot, M.-C., & Hen, R. (1994). Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor. Science. https://doi.org/10.1126/science.8091214
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