The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Induction of Type I Diabetes by Interferon-α in Transgenic Mice
Abstract
Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic β cells, and the immune system in a genetically susceptible host. The possibility that the type I interferons could mediate this interaction was tested with transgenic mice in which the insulin-producing β cells expressed an interferon-α. These mice developed a hypoinsulinemic diabetes associated with a mixed inflammation centered on the islets. The inflammation and the diabetes were prevented with a neutralizing antibody to the interferon-α. Thus, the expression of interferon-α by the β cells could be causal in the development of type I diabetes, which suggests a therapeutic approach to this disease.
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Cites
Eisenbarth (1986) · doi:10.1056/nejm198605223142106 · Cited by 1,659
Cited by
Marroqui, L., Dos Santos, R. S., Op de beeck, A., Coomans de Brachène, A., Marselli, L., Marchetti, P., & Eizirik, D. L. (2017) · Diabetologia · doi:10.1007/s00125-016-4201-3 · Cited by 203
Interferon-alpha and its effects on the cytokine cascade: a pro- and anti-inflammatory cytokine
Tilg, H., & Peschel, C. (1996) · Leukemia & Lymphoma · doi:10.3109/10428199609054802 · Cited by 34
Metadata
- Authors
- Stewart, T. A., Hultgren, B., Huang, X., Pitts-Meek, S., Hully, J., & MacLachlan, N. J.
- Venue
- Science
- Published
- 1993-06-25
- Volume
- 260
- Issue
- 5116
- Pages
- 1942-1946
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053274278
- Cited by
- 285
- References
- 1
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
