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Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85
Abstract
Induction of the yeast gene PHO5 is mediated by the transcription factors PHO2 and PHO4. PHO5 transcription is not detectable in high phosphate; it is thought that the negative regulators PHO80 and PHO85 inactivate PHO2 and PHO4. Here it is reported that PHO80 has homology to yeast cyclins and interacts with PHO85, a p34 cdc2/CDC28 -related protein kinase. The PHO80-PHO85 complex phosphorylates PHO4; this phosphorylation is correlated with negative regulation of PHO5 . These results demonstrate the existence of a cyclin-cdk complex that is used for a regulatory process other than cell-cycle control and identify a physiologically relevant substrate for this complex.
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Citations
Cited by
Morgan, D. O. (1995) · Nature · doi:10.1038/374131a0 · Cited by 3,284
Inhibitors of mammalian G1 cyclin-dependent kinases.
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,243
Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle
Nigg, E. A. (1995) · BioEssays · doi:10.1002/bies.950170603 · Cited by 932
O'Neill, E. M., Rebay, I., Tjian, R., & Rubin, G. M. (1994) · Cell · doi:10.1016/0092-8674(94)90580-0 · Cited by 675
Self-citationA novel cyclin associates with M015/CDK7 to form the CDK-activating kinase
Fisher, R. P., & Morgan, D. O. (1994) · Cell · doi:10.1016/0092-8674(94)90535-5 · Cited by 655
Metadata
- Authors
- Kaffman, A., Herskowitz, I., Tjian, R., & O'Shea, E. K.
- Venue
- Science
- Published
- 1994-02-25
- Volume
- 263
- Issue
- 5150
- Pages
- 1153-1156
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005222967
- Cited by
- 359
- References
- 0
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaffman, A., Herskowitz, I., Tjian, R., & O'Shea, E. K. (1994). Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85. Science. https://doi.org/10.1126/science.8108735
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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