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Characterization of Type I Receptors for Transforming Growth Factor-β and Activin
Abstract
Transforming growth factor-β (TGF-β) and activin exert their effects by binding to heteromeric complexes of type I and type II receptors. The type II receptors for TGF-β and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is described here. ALK-5 has been shown to be a functional TGF-β type I receptor. A systematic analysis revealed that most ALKs formed heteromeric complexes with the type II receptors for TGF-β and activin after overexpression in COS cells; however, among the six ALKs, only ALK-5 was a functional TGF-β type I receptor for activation of plasminogen activator inhibitor-1, and only ALK-2 and ALK-4 bound activin with high affinity.
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Cited by
Mechanism of activation of the TGF-β receptor
Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., & Massagué, J. (1994) · Nature · doi:10.1038/370341a0 · Cited by 2,337
Ichijo, H., Nishida, E., Irie, K., Dijke, P. T., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., & Gotoh, Y. (1997) · Science · doi:10.1126/science.275.5296.90 · Cited by 2,307
Self-citationInman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,634
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
Goumans, M.-J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1743 · Cited by 1,123
Johnson, D. W., Berg, J. N., Baldwin, M. A., Gallione, C. J., Marondel, I., Yoon, S.-J., Stenzel, T. T., Speer, M., Pericak-Vance, M. A., Diamond, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0696-189 · Cited by 1,116
Metadata
- Authors
- ten Dijke, P., Yamashita, H., Ichijo, H., Franzén, P., Laiho, M., Miyazono, K., & Heldin, C.-H.
- Venue
- Science
- Published
- 1994-04
- Volume
- 264
- Issue
- 5155
- Pages
- 101-104
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028854652
- Cited by
- 551
- References
- 0
- FWCI
- 18.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- ten Dijke, P., Yamashita, H., Ichijo, H., Franzén, P., Laiho, M., Miyazono, K., & Heldin, C.-H. (1994). Characterization of Type I Receptors for Transforming Growth Factor-β and Activin. Science. https://doi.org/10.1126/science.8140412
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