The DOI matches its Crossref record.
Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-dependent Concentration of Urine
Abstract
Concentration of urine in mammals is regulated by the antidiuretic hormone vasopressin. Binding of vasopressin to its V2 receptor leads to the insertion of water channels in apical membranes of principal cells in collecting ducts. In nephrogenic diabetes insipidus (NDI), the kidney fails to concentrate urine in response to vasopressin. A male patient with an autosomal recessive form of NDI was found to be a compound heterozygote for two mutations in the gene encoding aquaporin-2, a water channel. Functional expression studies in Xenopus oocytes revealed that each mutation resulted in nonfunctional water channel proteins. Thus, aquaporin-2 is essential for vasopressin-dependent concentration of urine.
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Citations
Cited by
Epidemiology, pathophysiology, and management of hyponatremic encephalopathy.
Fraser, C. L., & Arieff, A. I. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00274-4 · Cited by 288
Functional requirement of aquaporin-5 in plasma membranes of sweat glands
Nejsum, L. N., Kwon, T.-H., Jensen, U. B., Fumagalli, O., Frøkiaer, J., Krane, C. M., Menon, A. G., King, L. S., Agre, P. C., & Nielsen, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012588099 · Cited by 211
Novel roles of aquaporins revealed by phenotype analysis of knockout mice
Verkman, A. S. (2006) · Reviews of Physiology, Biochemistry, and Pharmacology · doi:10.1007/3-540-28217-3_2 · Cited by 97
Brown, M. B., Haack, K. K. V., Pollack, B. P., Millard-Stafford, M., & McCarty, N. A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00660.2010 · Cited by 45
Metadata
- Authors
- Deen, P. M. T., Verdijk, M. A. J., Knoers, N. V. A. M., Wieringa, B., Monnens, L. A. H., van Os, C. H., & van Oost, B. A.
- Venue
- Science
- Published
- 1994-04
- Volume
- 264
- Issue
- 5155
- Pages
- 92-95
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079126167
- Cited by
- 873
- References
- 0
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- closed
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