The DOI matches its Crossref record.
Gene for Familial Psoriasis Susceptibility Mapped to the Distal End of Human Chromosome 17q
Abstract
A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6 , two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.
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Citations
Cited by
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,413
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
Nickoloff, B. J., & Nestle, F. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422147 · Cited by 544
Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci
Cookson, W. O. C. M., Ubhi, B., Lawrence, R., Abecasis, G. R., Walley, A. J., Cox, H. E., Coleman, R., Leaves, N. I., Trembath, R. C., Moffatt, M. F., et al. (2001) · Nature Genetics · doi:10.1038/86867 · Cited by 379
Wang, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27180 · Cited by 276
Ramoz, N., Favre, M., Orth, G., Taïeb, A., Rueda, L.-A., Montoya, L.-S., & Bouadjar, B. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00996.x · Cited by 98
Metadata
- Authors
- Tomfohrde, J., Silverman, A., Barnes, R., Fernandez-Vina, M. A., Young, M., Lory, D., Morris, L., Wuepper, K. D., Stastny, P., Menter, A., & Bowcock, A.
- Venue
- Science
- Published
- 1994-05-20
- Volume
- 264
- Issue
- 5162
- Pages
- 1141-1145
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093065038
- Cited by
- 426
- References
- 0
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Gene for Familial Psoriasis Susceptibility Mapped to the Distal End of Human Chromosome 17q. https://app.cochat.ai/papers/10.1126/science.8178173
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- Tomfohrde, J., Silverman, A., Barnes, R., Fernandez-Vina, M. A., Young, M., Lory, D., Morris, L., Wuepper, K. D., Stastny, P., Menter, A., & Bowcock, A. (1994). Gene for Familial Psoriasis Susceptibility Mapped to the Distal End of Human Chromosome 17q. Science. https://doi.org/10.1126/science.8178173
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
