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Potentiation by the β Subunit of the Ratio of the Ionic Current to the Charge Movement in the Cardiac Calcium Channel
Abstract
The voltage-activated rabbit cardiac calcium channel α 1 subunit was expressed in Xenopus oocytes. The charge movement of its voltage sensor was measured and related to the opening of the ion-conducting pore. The half-activation potential for charge movement was 35 millivolts more negative than that for pore opening. Coexpression of the cardiac calcium channel β subunit reduced this difference without affecting charge movement. Thus, intramolecular coupling between the voltage sensor and the channel pore opening can be facilitated by a regulatory subunit.
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Cited by
Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
Rettig, J., Heinemann, S. H., Wunder, F., Lorra, C., Parcej, D. N., Oliver Dolly, J., & Pongs, O. (1994) · Nature · doi:10.1038/369289a0 · Cited by 852
The role of Ca2+ ions in excitation-contraction coupling of skeletal muscle fibres
Melzer, W., Herrmann-Frank, A., & Lüttgau, H. C. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(94)00014-5 · Cited by 548
Bichet, D., Cornet, V., Geib, S., Carlier, E., Volsen, S., Hoshi, T., Mori, Y., & De Waard, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)80881-8 · Cited by 377
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond
Dolphin, A. C. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3311 · Cited by 368
Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function
Walker, D., & De Waard, M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01200-9 · Cited by 360
Metadata
- Authors
- Neely, A., Wei, X., Olcese, R., Birnbaumer, L., & Stefani, E.
- Venue
- Science
- Published
- 1993-10-22
- Volume
- 262
- Issue
- 5133
- Pages
- 575-578
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071559339
- Cited by
- 250
- References
- 0
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Potentiation by the β Subunit of the Ratio of the Ionic Current to the Charge Movement in the Cardiac Calcium Channel. https://app.cochat.ai/papers/10.1126/science.8211185
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- Neely, A., Wei, X., Olcese, R., Birnbaumer, L., & Stefani, E. (1993). Potentiation by the β Subunit of the Ratio of the Ionic Current to the Charge Movement in the Cardiac Calcium Channel. Science. https://doi.org/10.1126/science.8211185
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
