The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Microdomains with High Ca 2+ Close to IP 3 -Sensitive Channels that Are Sensed by Neighboring Mitochondria
Abstract
Microdomains of high intracellular calcium ion concentration, [Ca 2+ ] i , have been hypothesized to occur in living cells exposed to stimuli that generate inositol 1,4,5-trisphosphate (IP 3 ). Mitochondrially targeted recombinant aequorin was used to show that IP 3 -induced Ca 2+ mobilization from intracellular stores caused increases of mitochondrial Ca 2+ concentration, [Ca 2+ ] m , the speed and amplitude of which are not accounted for by the relatively small increases in mean [Ca 2+ ] i . A similar response was obtained by the addition of IP 3 to permeabilized cells but not by perfusion of cells with Ca 2+ at concentrations similar to those measured in intact cells. It is concluded that in vivo, domains of high [Ca 2+ ] i are transiently generated close to IP 3 -gated channels and sensed by nearby mitochondria; this may provide an efficient mechanism for optimizing mitochondrial activity upon cell stimulation.
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Citations
Cites
Role of calcium ions in regulation of mammalian intramitochondrial metabolism
McCormack, J. G., Halestrap, A. P., & Denton, R. M. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.391 · Cited by 1,398
Cited by
The versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Mitochondria as sensors and regulators of calcium signalling
Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781
Self-citationThe mitochondrial calcium uniporter is a highly selective ion channel
Kirichok, Y., Krapivinsky, G., & Clapham, D. E. (2004) · Nature · doi:10.1038/nature02246 · Cited by 1,409
Metadata
- Authors
- Rizzuto, R., Brini, M., Murgia, M., & Pozzan, T.
- Venue
- Science
- Published
- 1993-10-29
- Volume
- 262
- Issue
- 5134
- Pages
- 744-747
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963791094
- Cited by
- 1,205
- References
- 1
- FWCI
- 11.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rizzuto, R., Brini, M., Murgia, M., & Pozzan, T. (1993). Microdomains with High Ca 2+ Close to IP 3 -Sensitive Channels that Are Sensed by Neighboring Mitochondria. Science. https://doi.org/10.1126/science.8235595
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
