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Elements of the Yeast Pheromone Response Pathway Required for Filamentous Growth of Diploids
Abstract
Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae , a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types.
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Metadata
- Authors
- Liu, H., Styles, C. A., & Fink, G. R.
- Venue
- Science
- Published
- 1993-12-10
- Volume
- 262
- Issue
- 5140
- Pages
- 1741-1744
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074204387
- Cited by
- 498
- References
- 0
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
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