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Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication
Abstract
The genes encoding two of the subunits of the Saccharomyces cerevisiae origin recognition complex (ORC) have been isolated. Characterization of a temperature-sensitive mutation in the gene encoding the 72-kD subunit of ORC ( ORC2 ) indicates that this protein complex functions early in the DNA replication process. Moreover, ORC derived from orc2 ts cells is defective for DNA binding. Others have shown a defect in orc2 ts cells in transcriptional silencing at the silent mating-type loci. Consistent with this finding, ORC specifically binds to each of the four mating-type silencers identified in yeast. These findings support the hypothesis that ORC acts as an initiator protein at yeast origins of DNA replication and suggest that ORC also functions in the determination of transcriptional domains.
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Cited by
A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex
Ishimi, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24508 · Cited by 538
High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling
Brar, G. A., Yassour, M., Friedman, N., Regev, A., Ingolia, N. T., & Weissman, J. S. (2012) · Science · doi:10.1126/science.1215110 · Cited by 533
Cell cycle control of DNA replication
Stillman, B. (1996) · Science · doi:10.1126/science.274.5293.1659 · Cited by 507
Self-citationChromosome Dynamics in the Yeast Interphase Nucleus
Heun, P., Laroche, T., Shimada, K., Furrer, P., & Gasser, S. M. (2001) · Science · doi:10.1126/science.1065366 · Cited by 470
Mills, K. D., Sinclair, D. A., & Guarente, L. (1999) · Cell · doi:10.1016/s0092-8674(00)80772-2 · Cited by 334
Metadata
- Authors
- Bell, S. P., Kobayashi, R., & Stillman, B.
- Venue
- Science
- Published
- 1993-12-17
- Volume
- 262
- Issue
- 5141
- Pages
- 1844-1849
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044279758
- Cited by
- 430
- References
- 0
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- closed
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