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Meiosis-Induced Double-Strand Break Sites Determined by Yeast Chromatin Structure
Abstract
Double-strand DNA breaks (DSBs) occur at recombination hotspots during Saccharomyces cerevisiae meiosis and are thought to initiate exchange at these loci. Analysis of DSB sites in three regions of the yeast genome indicated that breaks occur at or near many potential transcription promoters and that DSBs initiate most, if not all, meiotic recombination. DSB sites displayed deoxyribonuclease I hypersensitivity in chromatin from mitotic and meiotic cells, and changes in chromatin structure produced parallel changes in the occurrence of DSBs. Thus, features of chromatin structure that are established before meiosis play a role in determining where meiotic recombination events initiate.
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Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Jeffreys, A. J., Kauppi, L., & Neumann, R. (2001) · Nature Genetics · doi:10.1038/ng1001-217 · Cited by 835
Pan, J., Sasaki, M., Kniewel, R., Murakami, H., Blitzblau, H. G., Tischfield, S. E., Zhu, X., Neale, M. J., Jasin, M., Socci, N. D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.009 · Cited by 549
Kogoma, T. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.2.212-238.1997 · Cited by 532
Metadata
- Authors
- Wu, T.-C., & Lichten, M.
- Venue
- Science
- Published
- 1994-01-28
- Volume
- 263
- Issue
- 5146
- Pages
- 515-518
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988306770
- Cited by
- 443
- References
- 0
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wu, T.-C., & Lichten, M. (1994). Meiosis-Induced Double-Strand Break Sites Determined by Yeast Chromatin Structure. Science. https://doi.org/10.1126/science.8290959
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