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Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells
Abstract
A gene encoding a protein related to the serpin family of protease inhibitors was identified as a candidate tumor suppressor gene that may play a role in human breast cancer. The gene product, called maspin, is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. Transfection of MDA-MB-435 mammary carcinoma cells with the maspin gene did not alter the cells' growth properties in vitro, but reduced the cells' ability to induce tumors and metastasize in nude mice and to invade through a basement membrane matrix in vitro. Analysis of human breast cancer specimens revealed that loss of maspin expression occurred most frequently in advanced cancers. These results support the hypothesis that maspin functions as a tumor suppressor.
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Citations
Cited by
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180
Gudjonsson, T., Rønnov-Jessen, L., Villadsen, R., Rank, F., Bissell, M. J., & Petersen, O. W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.39 · Cited by 517
Tsai, S., McOlash, L., Palen, K., Johnson, B., Duris, C., Yang, Q., Dwinell, M. B., Hunt, B., Evans, D. B., Gershan, J., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-4238-4 · Cited by 400
Structure and properties of ovalbumin
Huntington, J. A., & Stein, P. E. (2001) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/s0378-4347(01)00108-6 · Cited by 380
S-Glutathionylation: From Molecular Mechanisms to Health Outcomes
Xiong, Y., Uys, J. D., Tew, K. D., & Townsend, D. M. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3540 · Cited by 314
Metadata
- Authors
- Zou, Z., Anisowicz, A., Hendrix, M. J. C., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Seftor, E., & Sager, R.
- Venue
- Science
- Published
- 1994-01-28
- Volume
- 263
- Issue
- 5146
- Pages
- 526-529
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981570640
- Cited by
- 912
- References
- 0
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells. https://app.cochat.ai/papers/10.1126/science.8290962
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- Zou, Z., Anisowicz, A., Hendrix, M. J. C., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Seftor, E., & Sager, R. (1994). Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells. Science. https://doi.org/10.1126/science.8290962
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
