The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor
Abstract
To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue located in a carboxyl-terminal tetrapeptide. Inhibitors of the enzyme that catalyzes this modification, farnesyl protein transfe ras e (FPTase), have therefore been suggested as anticancer agents for tumors in which Ras contributes to transformation. The tetrapeptide analog L-731,735 is a potent and selective inhibitor of FPTase in vitro. A prodrug of this compound, L-731,734, inhibited Ras processing in cells transformed with v- ras . L-731,734 decreased the ability of v- ras -transformed cells to form colonies in soft agar but had no effect on the efficiency of colony formation of cells transformed by either the v- raf or v- mos oncogenes. The results demonstrate selective inhibition of ras -dependent cell transformation with a synthetic organic inhibitor of FPTase.
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Cites
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Self-citationInhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.
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Sequence dependence of protein isoprenylation
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Self-citation
Cited by
Epidermal growth factor-related peptides and their receptors in human malignancies
Salomon, D. S., Brandt, R., Ciardiello, F., & Normanno, N. (1995) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(94)00144-i · Cited by 2,690
Tyrosine Kinase Inhibition: An Approach to Drug Development
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Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588
K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors
Whyte, D. B., Kirschmeier, P., Hockenberry, T. N., Nunez-Oliva, I., James, L., Catino, J. J., Bishop, W. R., & Pai, J.-K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14459 · Cited by 884
Ras history: The saga continues
Cox, A. D., & Der, C. J. (2010) · Small GTPases · doi:10.4161/sgtp.1.1.12178 · Cited by 706
Metadata
- Authors
- Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., & Gibbs, J. B.
- Venue
- Science
- Published
- 1993-06-25
- Volume
- 260
- Issue
- 5116
- Pages
- 1934-1937
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036082581
- Cited by
- 579
- References
- 34
- FWCI
- 19.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., & Gibbs, J. B. (1993). Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor. Science. https://doi.org/10.1126/science.8316833
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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