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Cited by 871

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation

Hamer, Dean H., Hu, Stella, Magnuson, Victoria L., Hu, Nan, Pattatucci, Angela M. L.·1993·Science
DOI 10.1126/science.8332896
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Abstract

The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 ( P = 10 -5 ), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced.

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Metadata

Authors
Hamer, D. H., Hu, S., Magnuson, V. L., Hu, N., & Pattatucci, A. M. L.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-07-16
Volume
261
Issue
5119
Pages
321-327
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8332896
OpenAlex
W2035614594
Cited by
871
References
1
FWCI
13.74
Type
journal article
Language
en
Open access
closed

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