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Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice
Abstract
The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk , was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.
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Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
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THE HIGH-AFFINITY I g E RECEPTOR (FcεRI): From Physiology to Pathology
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Metadata
- Authors
- Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazan, J. F., Howard, M., Copeland, N. G., Jenkins, N. A., & Witte, O. N.
- Venue
- Science
- Published
- 1993-07-16
- Volume
- 261
- Issue
- 5119
- Pages
- 358-361
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054526083
- Cited by
- 856
- References
- 1
- FWCI
- 26.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazan, J. F., Howard, M., Copeland, N. G., Jenkins, N. A., & Witte, O. N. (1993). Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice. Science. https://doi.org/10.1126/science.8332901
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