The DOI matches its Crossref record.
An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain
Abstract
The efficient introduction of genetic material into quiescent nerve cells is important in the study of brain function and for gene therapy of neurological disorders. A replication-deficient adenoviral vector that contained a reporter gene encoding β-galactosidase infected rat nerve cells in vitro and in vivo. β-Galactosidase was expressed in almost all sympathetic neurons and astrocytes in culture. After stereotactic inoculations into the rat hippocampus and the substantia nigra, β-galactosidase activity was detected for 2 months. Infected cells were identified as microglial cells, astrocytes, or neurons with anatomical, morphological, and immunohistochemical criteria. No obvious cytopathic effect was observed.
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Citations
Cited by
Glutamate receptors in the mammalian central nervous system
Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,122
Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., & Saito, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1320 · Cited by 788
Determinants of nucleosome positioning
Struhl, K., & Segal, E. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2506 · Cited by 686
Packaging capacity and stability of human adenovirus type 5 vectors
Bett, A. J., Prevec, L., & Graham, F. L. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.5911-5921.1993 · Cited by 472
McCown, T. J., Xiao, X., Li, J., Breese, G. R., & Jude Samulski, R. (1996) · Brain Research · doi:10.1016/0006-8993(95)01488-8 · Cited by 450
Metadata
- Authors
- La Salle, G. L. G., Robert, J. J., Berrard, S., Ridoux, V., Stratford-Perricaudet, L. D., Perricaudet, M., & Mallet, J.
- Venue
- Science
- Published
- 1993-02-12
- Volume
- 259
- Issue
- 5097
- Pages
- 988-990
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083430062
- Cited by
- 738
- References
- 0
- FWCI
- 53.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- La Salle, G. L. G., Robert, J. J., Berrard, S., Ridoux, V., Stratford-Perricaudet, L. D., Perricaudet, M., & Mallet, J. (1993). An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain. Science. https://doi.org/10.1126/science.8382374
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
