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Expression cloning and signaling properties of the rat glucagon receptor
Abstract
Glucagon and the glucagon receptor are a primary source of control over blood glucose concentrations and are especially important to studies of diabetes in which the loss of control over blood glucose concentrations clinically defines the disease. A complementary DNA clone for the glucagon receptor was isolated by an expression cloning strategy, and the receptor protein was expressed in several kidney cell lines. The cloned receptor bound glucagon and caused an increase in the intracellular concentration of adenosine 3', 5'-monophosphate (cAMP). The cloned glucagon receptor also transduced a signal that led to an increased concentration of intracellular calcium. The glucagon receptor is similar to the calcitonin and parathyroid hormone receptors. It can transduce signals leading to the accumulation of two different second messengers, cAMP and calcium.
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Citations
Cited by
Glucagon and regulation of glucose metabolism
Jiang, G., & Zhang, B. B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00492.2002 · Cited by 905
Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237106100 · Cited by 563
Chang, C.-P., Pearse, R. V., O'Connell, S., & Rosenfeld, M. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90230-o · Cited by 537
Usdin, T. B., Mezey, E., Button, D. C., Brownstein, M. J., & Bonner, T. I. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243312 · Cited by 534
The metabolic actions of glucagon revisited
Habegger, K. M., Heppner, K. M., Geary, N., Bartness, T. J., DiMarchi, R., & Tschöp, M. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.187 · Cited by 406
Metadata
- Authors
- Jelinek, L., Lok, S., Rosenberg, G., Smith, R., Grant, F., Biggs, S., Bensch, P., Kuijper, J., Sheppard, P., Sprecher, C., & et, A.
- Venue
- Science
- Published
- 1993-03-12
- Volume
- 259
- Issue
- 5101
- Pages
- 1614-1616
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039911916
- Cited by
- 397
- References
- 0
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jelinek, L., Lok, S., Rosenberg, G., Smith, R., Grant, F., Biggs, S., Bensch, P., Kuijper, J., Sheppard, P., Sprecher, C., & et, A. (1993). Expression cloning and signaling properties of the rat glucagon receptor. Science. https://doi.org/10.1126/science.8384375
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