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Calcium Mobilization by Dual Receptors During Fertilization of Sea Urchin Eggs
Abstract
Fertilization is accompanied by a transient increase in the concentration of intracellular Ca 2+ , which serves as a signal for initiating development. Some of the Ca 2+ appears to be released from intracellular stores by the binding of inositol trisphosphate (IP 3 ) to its receptor. However, in sea urchin eggs, other mechanisms appear to participate. Cyclic adenosine diphosphate-ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide, is as potent as IP 3 in mobilizing Ca 2+ in sea urchin eggs. Experiments with antagonists of the cADPR and IP 3 receptors revealed that both Ca 2+ mobilizing systems were activated during fertilization. Blockage of either of the systems alone was not sufficient to prevent the sperm-induced Ca 2+ transient. This study provides direct evidence for a physiological role of cADPR in the Ca 2+ signaling process.
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Citations
Cited by
Calcium at Fertilization and in Early Development
Whitaker, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2005 · Cited by 512
Endoplasmic reticulum of animal cells and its organization into structural and functional domains
Baumann, O., & Walz, B. (2001) · International Review of Cytology · doi:10.1016/s0074-7696(01)05004-5 · Cited by 458
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Lee, H. C. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.317 · Cited by 433
Self-citationEgg Activation at Fertilization: Where It All Begins
Runft, L. L., Jaffe, L. A., & Mehlmann, L. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0600 · Cited by 364
Berridge, M. J. (1993) · Nature · doi:10.1038/365388a0 · Cited by 340
Metadata
- Authors
- Lee, H. C., Aarhus, R., & Walseth, T. F.
- Venue
- Science
- Published
- 1993-07-16
- Volume
- 261
- Issue
- 5119
- Pages
- 352-355
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006265135
- Cited by
- 293
- References
- 0
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, H. C., Aarhus, R., & Walseth, T. F. (1993). Calcium Mobilization by Dual Receptors During Fertilization of Sea Urchin Eggs. Science. https://doi.org/10.1126/science.8392749
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