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Human c- myc Transcription Factor PuF Identified as nm23-H2 Nucleoside Diphosphate Kinase, a Candidate Suppressor of Tumor Metastasis
Abstract
A human gene encoding the c- myc purine-binding transcription factor PuF was identified by screening of a cervical carcinoma cell complementary DNA library with a DNA fragment containing PuF binding sites. The 17-kilodalton bacterially produced PuF was shown to have biological activity and properties similar to that of human PuF. DNA sequence analysis of recombinant PuF revealed perfect identity with the human nm23-H2 nucleoside diphosphate kinase gene, a potential negative regulator of cancer metastasis. These results provide a link between nm23 and the c- myc oncogene and suggest that the nm23 protein can function in vitro in the transcriptional regulation of c- myc expression.
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Cited by
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Brooks, T. A., Kendrick, S., & Hurley, L. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07759.x · Cited by 477
Heterogeneous Nuclear Ribonucleoprotein K Is a Transcription Factor
Michelotti, E. F., Michelotti, G. A., Aronsohn, A. I., & Levens, D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2350 · Cited by 353
Mirkin, S. M., & Frank-Kamenetskii, M. D. (1994) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.bb.23.060194.002545 · Cited by 257
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211
Metadata
- Authors
- Postel, E. H., Berberich, S. J., Flint, S. J., & Ferrone, C. A.
- Venue
- Science
- Published
- 1993-07-23
- Volume
- 261
- Issue
- 5120
- Pages
- 478-480
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057234832
- Cited by
- 495
- References
- 0
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Human c- myc Transcription Factor PuF Identified as nm23-H2 Nucleoside Diphosphate Kinase, a Candidate Suppressor of Tumor Metastasis. https://app.cochat.ai/papers/10.1126/science.8392752
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- Postel, E. H., Berberich, S. J., Flint, S. J., & Ferrone, C. A. (1993). Human c- myc Transcription Factor PuF Identified as nm23-H2 Nucleoside Diphosphate Kinase, a Candidate Suppressor of Tumor Metastasis. Science. https://doi.org/10.1126/science.8392752
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
