The DOI matches its Crossref record.
The Prevention of Thymic Lymphomas in Transgenic Mice by Human O 6 -Alkylguanine-DNA Alkyltransferase
Abstract
Nitrosoureas form O 6 -alkylguanine-DNA adducts that are converted to G to A transitions, the mutation found in the activated ras oncogenes of nitrosourea-induced mouse lymphomas and rat mammary tumors. These adducts are removed by the DNA repair protein O 6 -alkylguanine-DNA alkyltransferase. Transgenic mice that express the human homolog of this protein in the thymus were found to be protected from developing thymic lymphomas after exposure to N -methyl- N -nitrosourea. Thus, transgenic expression of a single human DNA repair gene is sufficient to block chemical carcinogenesis. The transduction of DNA repair genes in vivo may unravel mechanisms of carcinogenesis and provide therapeutic protection from known carcinogens.
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Citations
Cited by
DNA repair mechanisms in dividing and non-dividing cells
Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697
Park, S. Y., Kim, K.-S., Lee, Y.-M., Kim, M.-J., Jacobs, D. R., Porta, M., Kim, D.-S., & Lee, D.-H. (2015) · Biomarkers · doi:10.3109/1354750x.2014.1002806 · Cited by 11
Metadata
- Authors
- Dumenco, L. L., Allay, E., Norton, K., & Gerson, S. L.
- Venue
- Science
- Published
- 1993-01-08
- Volume
- 259
- Issue
- 5092
- Pages
- 219-222
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018938581
- Cited by
- 236
- References
- 0
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Prevention of Thymic Lymphomas in Transgenic Mice by Human O 6 -Alkylguanine-DNA Alkyltransferase. https://app.cochat.ai/papers/10.1126/science.8421782
- The paper
- Dumenco, L. L., Allay, E., Norton, K., & Gerson, S. L. (1993). The Prevention of Thymic Lymphomas in Transgenic Mice by Human O 6 -Alkylguanine-DNA Alkyltransferase. Science. https://doi.org/10.1126/science.8421782
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
