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A wingless -Dependent Polar Coordinate System in Drosophila Imaginal Discs
Abstract
The patterning of the imaginal discs in Drosophila melanogaster is a progressive process that, like the patterning of the larval epidermis during embryogenesis, requires the activity of segment polarity genes. One segment polarity gene, wingless , encodes a homolog of the mouse proto-oncogene Wnt-1 and plays a prominent role in the patterning of the larval epidermis and the imaginal discs. However, whereas the function of wingless in the embryo is initially associated with a pattern of stripes along the anteroposterior axis that are part of a Cartesian coordinate system, it is shown here that during imaginal development wingless is associated with a pattern of sectors that provide references for a polar coordinate system homologous to that postulated in a well-known model for the regeneration of insect and vertebrate limbs.
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Cited by
Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M., & Tabin, C. (1995) · Cell · doi:10.1016/0092-8674(95)90103-5 · Cited by 478
Targeted disruption of the Wnt2 gene results in placentation defects
Monkley, S. J., Delaney, S. J., Pennisi, D. J., Christiansen, J. H., & Wainwright, B. J. (1996) · Development · doi:10.1242/dev.122.11.3343 · Cited by 357
The wingless signalling pathway and the patterning of the wing margin in Drosophila
Couso, J. P., Bishop, S. A., & Arias, A. M. (1994) · Development · doi:10.1242/dev.120.3.621 · Cited by 355
Self-citationRegenerative Growth in Drosophila Imaginal Discs Is Regulated by Wingless and Myc
Smith-Bolton, R. K., Worley, M. I., Kanda, H., & Hariharan, I. K. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.04.015 · Cited by 288
Regulation and Regeneration in the Ctenophore Mnemiopsis leidyi
Henry, J. Q., & Martindale, M. Q. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9903 · Cited by 46
Metadata
- Authors
- Couso, J. P., Bate, M., & Martínez-Arias, A.
- Venue
- Science
- Published
- 1993-01-22
- Volume
- 259
- Issue
- 5094
- Pages
- 484-489
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026377725
- Cited by
- 268
- References
- 0
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Couso, J. P., Bate, M., & Martínez-Arias, A. (1993). A wingless -Dependent Polar Coordinate System in Drosophila Imaginal Discs. Science. https://doi.org/10.1126/science.8424170
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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