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Ancient Conserved Regions in New Gene Sequences and the Protein Databases
Abstract
Sets of new gene sequences from human, nematode, and yeast were compared with each other and with a set of Escherichia coli genes in order to detect ancient evolutionarily conserved regions (ACRs) in the encoded proteins. Nearly all of the ACRs so identified were found to be homologous to sequences in the protein databases. This suggests that currently known proteins may already include representatives of most ACRs and that new sequences not similar to any database sequence are unlikely to contain ACRs. Preliminary analyses indicate that moderately expressed genes may be more likely to contain ACRs than rarely expressed genes. It is estimated that there are fewer than 900 ACRs in all.
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Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Self-citationA minimal gene set for cellular life derived by comparison of complete bacterial genomes
Mushegian, A. R., & Koonin, E. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10268 · Cited by 916
Birney, E., Kumar, S., & Krainer, A. R. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.25.5803 · Cited by 668
Newman, T., de Bruijn, F. J., Green, P., Keegstra, K., Kende, H., McIntosh, L., Ohlrogge, J., Raikhel, N., Somerville, S., Thomashow, M., et al. (1994) · Plant Physiology · doi:10.1104/pp.106.4.1241 · Cited by 632
Self-citationComparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
Zdobnov, E. M., von Mering, C., Letunic, I., Torrents, D., Suyama, M., Copley, R. R., Christophides, G. K., Thomasova, D., Holt, R. A., Subramanian, G. M., et al. (2002) · Science · doi:10.1126/science.1077061 · Cited by 553
Metadata
- Authors
- Green, P., Lipman, D., Hillier, L., Waterston, R., States, D., & Claverie, J.-M.
- Venue
- Science
- Published
- 1993-03-19
- Volume
- 259
- Issue
- 5102
- Pages
- 1711-1716
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976658858
- Cited by
- 178
- References
- 0
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Green, P., Lipman, D., Hillier, L., Waterston, R., States, D., & Claverie, J.-M. (1993). Ancient Conserved Regions in New Gene Sequences and the Protein Databases. Science. https://doi.org/10.1126/science.8456298
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