The DOI matches its Crossref record.
Genetic Mapping of a Locus Predisposing to Human Colorectal Cancer
Abstract
Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.
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Cited by
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Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
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Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
Molecular Genetics of Colorectal Cancer
Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662
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Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581
Pathologic Predictors of Microsatellite Instability in Colorectal Cancer
Greenson, J. K., Huang, S.-C., Herron, C., Moreno, V., Bonner, J. D., Tomsho, L. P., Ben-Izhak, O., Cohen, H. I., Trougouboff, P., Bejhar, J., et al. (2009) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31817ec2b1 · Cited by 286
P.Leeflang, E., Zhang, L., Tavare, S., Hubert, R., Srinidhi, J., E.MacDonald, M., H.Myers, R., Young, M. D., S.Wexler, N., F.Gusella, J., et al. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.9.1519 · Cited by 182
Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis.
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Metadata
- Authors
- Peltomäki, P., Aaltonen, L. A., Sistonen, P., Pylkkänen, L., Mecklin, J.-P., Järvinen, H., Green, J. S., Jass, J. R., Weber, J. L., Leach, F. S., Petersen, G. M., Hamilton, S. R., de la Chapelle, A., & Vogelstein, B.
- Venue
- Science
- Published
- 1993-05-07
- Volume
- 260
- Issue
- 5109
- Pages
- 810-812
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080952568
- Cited by
- 930
- References
- 0
- FWCI
- 74.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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