Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 213

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein

Wang, Chung-Yih, Petryniak, Bronislawa, Thompson, Craig B., Kaelin, William G., Leiden, Jeffrey M.·1993·Science
DOI 10.1126/science.8493578
Open this paper in CoChat — free account

Abstract

The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression. Elf-1 is a lymphoid-specific Ets transcription factor that regulates inducible gene expression during T cell activation. In this report, it is demonstrated that Elf-1 contains a sequence motif that is highly related to the Rb binding sites of several viral oncoproteins and binds to the pocket region of Rb both in vitro and in vivo. Elf-1 binds exclusively to the underphosphorylated form of Rb and fails to bind to Rb mutants derived from patients with retinoblastoma. Co-immunoprecipitation experiments demonstrated an association between Elf-1 and Rb in resting normal human T cells. After T cell activation, the phosphorylation of Rb results in the release of Elf-1, which is correlated temporally with the activation of Elf-1-mediated transcription. Overexpression of a phosphorylation-defective form of Rb inhibited Elf-1-dependent transcription during T cell activation. These results demonstrate that Rb interacts specifically with a lineage-restricted Ets transcription factor. This regulated interaction may be important for the coordination of lineage-specific effector functions such as lymphokine production with cell cycle progression in activated T cells.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.8493578

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Research works printed but not linked: 43

  1. 10.1016/S0065-2776(08)60756-7 · DOI · Paper page
  2. 10.1016/0092-8674(91)90558-G · DOI · Paper page
  3. 10.1038/352249a0 · DOI · Paper page
  4. BOISE, L.H., THE NFAT-1 DNA-BINDING COMPLEX IN ACTIVATED T-CELLS CONTAINS FRA-1 AND JUNB, MOLECULAR AND CELLULAR BIOLOGY 13: 1911 (1993).
  5. BOSSELUT, R, THE PRODUCT OF THE C-ETS-1 PROTOONCOGENE AND THE RELATED ETS2 PROTEIN ACT AS TRANSCRIPTIONAL ACTIVATORS OF THE LONG TERMINAL REPEAT OF HUMAN T-CELL LEUKEMIA-VIRUS HTLV-1, EMBO JOURNAL 9: 3137 (1990). · DOI · Paper page
  6. 10.1016/0092-8674(89)90508-4 · DOI · Paper page
  7. 10.1016/0092-8674(91)90557-F · DOI · Paper page
  8. 10.1016/0092-8674(91)90559-H · DOI · Paper page
  9. 10.1126/science.2783497 · DOI · Paper page
  10. 10.1016/0092-8674(88)90559-4 · DOI · Paper page
  11. DEFEOJONES, D, CLONING OF CDNAS FOR CELLULAR PROTEINS THAT BIND TO THE RETINOBLASTOMA GENE-PRODUCT, NATURE 352: 251 (1991). · DOI · Paper page
  12. 10.1126/science.3175621 · DOI · Paper page
  13. 10.1128/jvi.64.3.1353-1356.1990 · DOI · Paper page
  14. EWEN, M.E., AN N-TERMINAL TRANSFORMATION-GOVERNING SEQUENCE OF SV40 LARGE T-ANTIGEN CONTRIBUTES TO THE BINDING OF BOTH P110RB AND A 2ND CELLULAR PROTEIN, P120, CELL 58: 257 (1989). · DOI · Paper page
  15. 10.1016/0092-8674(91)90038-Z · DOI · Paper page
  16. 10.1073/pnas.84.24.9059 · DOI · Paper page
  17. 10.1126/science.2885916 · DOI · Paper page
  18. GLUZMAN, Y, SV40-TRANSFORMED SIMIAN CELLS SUPPORT THE REPLICATION OF EARLY SV40 MUTANTS, CELL 23: 175 (1981). · DOI · Paper page
  19. GOODRICH, D.W., THE RETINOBLASTOMA GENE-PRODUCT REGULATES PROGRESSION THROUGH THE G1 PHASE OF THE CELL-CYCLE, CELL 67: 293 (1991). · DOI · Paper page
  20. GUNTHER, C.V., SEQUENCE-SPECIFIC DNA-BINDING OF THE PROTO-ONCOPROTEIN ETS-1 DEFINES A TRANSCRIPTIONAL ACTIVATOR SEQUENCE WITHIN THE LONG TERMINAL REPEAT OF THE MOLONEY MURINE SARCOMA-VIRUS, GENES & DEVELOPMENT 4: 667 (1990). · DOI · Paper page
  21. HAMEL, P.A., TRANSCRIPTIONAL REPRESSION OF THE E2-CONTAINING PROMOTERS EIIAE, C-MYC, AND RB1 BY THE PRODUCT OF THE RB1 GENE, MOLECULAR AND CELLULAR BIOLOGY 12: 3431 (1992).
  22. HELIN, K, A CDNA-ENCODING A PRB-BINDING PROTEIN WITH PROPERTIES OF THE TRANSCRIPTION FACTOR E2F, CELL 70: 337 (1992). · DOI · Paper page
  23. 10.1126/science.2521957 · DOI · Paper page
  24. 10.1002/j.1460-2075.1990.tb08221.x · DOI · Paper page
  25. 10.1002/j.1460-2075.1990.tb08306.x · DOI · Paper page
  26. 10.1038/350160a0 · DOI
  27. 10.1016/0092-8674(91)90236-R · DOI · Paper page
  28. KAELIN, W.G., EXPRESSION CLONING OF A CDNA-ENCODING A RETINOBLASTOMA-BINDING PROTEIN WITH E2F-LIKE PROPERTIES, CELL 70: 351 (1992). · DOI · Paper page
  29. KAELIN, W.G., DEFINITION OF THE MINIMAL SIMIAN VIRUS-40 LARGE T-ANTIGEN-BINDING AND ADENOVIRUS E1A-BINDING DOMAIN IN THE RETINOBLASTOMA GENE-PRODUCT, MOLECULAR AND CELLULAR BIOLOGY 10: 3761 (1990).
  30. 10.1016/0092-8674(86)90386-7 · DOI · Paper page
  31. 10.1126/science.3823889 · DOI · Paper page
  32. LEIDEN, J.M., TRANSCRIPTIONAL REGULATION DURING T-CELL DEVELOPMENT - THE ALPHA-TCR GENE AS A MOLECULAR-MODEL, IMMUNOLOGY TODAY 13: 22 (1992). · DOI
  33. LEIDEN, J.M., A NOVEL ETS-RELATED TRANSCRIPTION FACTOR, ELF-1, BINDS TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 REGULATORY ELEMENTS THAT ARE REQUIRED FOR INDUCIBLE TRANSACTIVATION IN T-CELLS, JOURNAL OF VIROLOGY 66: 5890 (1992). · DOI
  34. LEWIN, B, DRIVING THE CELL-CYCLE - M-PHASE KINASE, ITS PARTNERS, AND SUBSTRATES, CELL 61: 743 (1990). · DOI · Paper page
  35. LIN, BTY, RETINOBLASTOMA CANCER SUPPRESSOR GENE-PRODUCT IS A SUBSTRATE OF THE CELL-CYCLE REGULATOR CDC2 KINASE, EMBO JOURNAL 10: 857 (1991). · DOI · Paper page
  36. 10.1016/0092-8674(89)90983-5 · DOI · Paper page
  37. 10.1038/352541a0 · DOI · Paper page
  38. SHIRODKAR, S, THE TRANSCRIPTION FACTOR E2F INTERACTS WITH THE RETINOBLASTOMA PRODUCT AND A P107-CYCLIN-A COMPLEX IN A CELL CYCLE-REGULATED MANNER, CELL 68: 157 (1992). · DOI · Paper page
  39. THOMPSON, C.B., CIS-ACTING SEQUENCES REQUIRED FOR INDUCIBLE INTERLEUKIN-2 ENHANCER FUNCTION BIND A NOVEL ETS-RELATED PROTEIN, ELF-1, MOLECULAR AND CELLULAR BIOLOGY 12: 1043 (1992).
  40. WANG, C.Y., EVOLUTIONARILY CONSERVED ETS FAMILY MEMBERS DISPLAY DISTINCT DNA-BINDING SPECIFICITIES, JOURNAL OF EXPERIMENTAL MEDICINE 175: 1391 (1992). · DOI · Paper page
  41. WATSON, D.K., MAMMALIAN ETS-1 AND ETS-2 GENES ENCODE HIGHLY CONSERVED PROTEINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 7862 (1988).
  42. 10.1016/0092-8674(89)90984-7 · DOI · Paper page
  43. YEE, A.S., THE ADENOVIRUS-INDUCIBLE FACTOR E2F STIMULATES TRANSCRIPTION AFTER SPECIFIC DNA-BINDING, MOLECULAR AND CELLULAR BIOLOGY 9: 578 (1989).

Cited by

See all 213

Metadata

Authors
Wang, C.-Y., Petryniak, B., Thompson, C. B., Kaelin, W. G., & Leiden, J. M.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-05-28
Volume
260
Issue
5112
Pages
1330-1335
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8493578
OpenAlex
W2091564367
Cited by
213
References
8
FWCI
13.53
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein. https://app.cochat.ai/papers/10.1126/science.8493578
The paper
Wang, C.-Y., Petryniak, B., Thompson, C. B., Kaelin, W. G., & Leiden, J. M. (1993). Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein. Science. https://doi.org/10.1126/science.8493578

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.