Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

Perry, Rachel J., Zhang, Dongyan, Zhang, Xian-Man, Boyer, James L., Shulman, Gerald I.·2015·Science
DOI 10.1126/science.aaa0672

Cited by (283)

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  2. Weak C–H acids as protonophores can carry hydrogen ions through lipid membranes and mitochondria: a case of o-carborane
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  4. The quest to burn fat, effortlessly and safely
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  5. A review: Anti-obesity drug discovery from natural plant metabolites and endogenous peptides
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  6. Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice
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  7. Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome.
    B. G. dos Santos, Niki F. Brisnovali, Leigh Goedeke · 2024 · Biochemical Journal
  8. Medication targeting to subcellular organelles: Emphasizing mitochondria as a therapeutic marvel—Current situation and future prospects
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  10. Update on lipid species and paediatric nonalcoholic fatty liver disease
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  11. Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
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  12. Non‐alcoholic Fatty Liver Disease and Insulin Resistance
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  13. Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice
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  15. Methylation of Phenyl Rings in Ester‐Stabilized Phosphorus Ylides Vastly Enhances Their Protonophoric Activity
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  16. New Antidiabetes Agent Targeting Both Mitochondrial Uncoupling and Pyruvate Catabolism: Two Birds With One Stone
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  17. Anilinopyrazines as potential mitochondrial uncouplers
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  18. Здоровое старение: антиоксиданты, разобщители и/или теломераза?
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  19. The effect of 12 week-maximum fat oxidation (FATmax) intensity exercise on microvascular function in obese patients with nonalcoholic fatty liver disease and its mechanism
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  20. Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function
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  21. Diverting hepatic lipid fluxes with lifestyles revision and pharmacological interventions as a strategy to tackle steatotic liver disease (SLD) and hepatocellular carcinoma (HCC)
    Davide Misceo, Gabriele Mocciaro, Simona D’Amore, Michèle Vacca · 2024 · Nutrition & Metabolism
  22. Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)
    Yuki Inoue, Yuko Wada, Makoto Sato, Seiji Sato, Takashi Okamoto, Naohide Kanemoto · 2023 · Toxicological Research
  23. Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro
    Alberto Camacho‐Morales, Juan Carlos Segoviano-Ramírez, Adriana Sánchez‐García, Jose de Jesus Herrera-de la Rosa, Jaime García‐Juárez, Carlos Alberto Hernandez-Puente, Geovana Calvo‐Anguiano, Sergio Rodolfo Maltos-Uro, Alejandra Olguin, Gabriel Gojon-Romanillos et al. · 2018 · Lipids in Health and Disease
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  27. Liposomal Form of 2,4-Dinitrophenol Lipophilic Derivatives as a Promising Therapeutic Agent for ATP Synthesis Inhibition
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  31. 2,4-Dinitrophenol Downregulates Genes for Diabetes and Fatty Liver in Obese Mice
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  44. Uncouplers of mitochondrial oxidation in non-alcoholic fatty liver disease
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  45. Future Treatments of NASH
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  47. Preclinical safety profile of a liver-localized mitochondrial uncoupler: OPC-163493
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  48. Liver toxicity produced by the weight reducing agent 2,4 dinitrophenol
    Omar M. E. Abdel‐Salam, Fatma A. Morsy, Dalia Medhat, Noha N. Yassen, Marwa El-Araby Shabana · 2023 · Drug Discovery
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    Qian Gao, He Jiang, Tao Liao, Yan-Ping Chen, Li-Li Tan, Jida Zhang, Chang-Qing Li, Qing Zeng, Qi Wang, Shuiqing Huang et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Developmental Programming of Nonalcoholic Fatty Liver Disease (NAFLD)
    Kimberley D. Bruce, Felino Ramon A. Cagampang · 2016 · Springer eBooks
  51. Les médicaments de l’obésité : état actuel et futures avancées
    Pierre Bel Lassen, Judith Aron‐Wisnewsky · 2023 · Cahiers de Nutrition et de Diététique
  52. A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice
    Bernardo Gindri dos Santos, Niki F. Brisnovali, Connor Haney, Myles Coven, Homa Linda Sebzevari, Lena Gaebel, Xinbo Zhang, Jonathan Sun, Alberto Canfrán‐Duque, Noemí Rotllán et al. · 2026 · Science Translational Medicine
  53. Diabetestherapie bei nichtalkoholischer Fettlebererkrankung
    Kálmán Benedikt Bódis, Michael Roden · 2016 · Der Diabetologe
  54. Master role of glucose-6-phosphate in cell signaling and consequences of its deregulation in the liver and kidneys
    Fabienne Rajas, Gilles Mithieux · 2019 · Elsevier eBooks
  55. Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function
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  56. Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions
    Karen R. Jonscher, Kimberley D. Bruce · 2019 · Advances in experimental medicine and biology
  57. State of Knowledge and Recent Advances in Prevention and Treatment of Mitochondrial Dysfunction in Obesity and Type 2 Diabetes
    Carles Cantó · 2019 · Elsevier eBooks
  58. Biomarkers of Insulin Resistance
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  59. Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment
    Chuwei Yu, Jing Chen, Jin Ren · 2022 · Molecular Biology Reports
  60. Herbal medicine of Kursi Wufarikun Ziyabit inhibits mitochondrial ATP production to activate AMPK in hepatocytes in therapy of type 2 diabetes
    Mireguli Yasen, Lan Jiang, Mizhgona Umedzhonovna Sharofova, Xuelei Xin, Yusuf Nuraliev, Jianping Ye, Haji Akber Aisa · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  61. A liver-specific mitochondrial carrier that controls gluconeogenesis and energy expenditure
    Jin-Seon Yook, Zachary H. Taxin, Bo Yuan, Satoshi Oikawa, Christopher Auger, Beste Mutlu, Pere Puigserver, Sheng Tony Hui, Shingo Kajimura · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Macroscopic label-free biomedical imaging with shortwave infrared Raman scattering
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  63. Kohlenhydratstoffwechsel der Leber
    Jocelyn de Heer · 2016 · Der Diabetologe
  64. Structurally distinct oligomers of islet amyloid polypeptide mediate toxic and non-toxic membrane poration
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  65. O microRNA miR-696 regula a expressão da proteína PGC-1α e induz à disfunção mitocondrial em células musculares de camundongos através do sistema SNARK/miR-696/PGC-1α
    André Lima Queiroz · 2017
  66. Thirteenth World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease
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  67. Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes
    Kenneth J. Cusi · 2017 · Contemporary diabetes
  68. Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity
    Alexandre Prola, Jordan Blondelle, Aymeline Vandestienne, Jérôme Piquereau, R Denis, Stéphane Guyot, Hadrien Chauvin, Arnaud Mourier, Martine Letheule, Marie Maurer et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
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  71. Faculty Opinions recommendation of Regulation of hepatic glucose metabolism in health and disease.
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  72. Proof of concept for a new type 2 diabetes mellitus therapy
    2015 · Nature Reviews Endocrinology
  73. The role of hepatic mitochondrial function and mitochondrial turnover in the development and progression of nonalcoholic fatty liver disease and lifestyle modifications to treat the disease
    Mary P. Moore · 2021
  74. Role of Galactose, Thiazolidinediones, and NEET proteins in Mitochondrial physiology and therapeutic development.
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  75. Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice
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