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Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling
Open accessAbstract
Membrane potential regulates growth: Changes in electrical potential across the plasma membrane can affect cell growth. Zhou et al. discovered that membrane potential influenced the organization of phospholipids in the membrane of cultured mammalian cells and neurons in intact flies (see the Perspective by Accardi). This in turn regulated localization and activity of the small guanine nucleotide binding protein K-Ras, an important regulator of cell proliferation. The cell membrane may thus function analogously to a field-effect transistor by adjusting the strength of mitogenic signaling. Science , this issue p. 873 ; see also p. 789
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Cites
Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle
Blackiston, D. J., McLaughlin, K. A., & Levin, M. (2009) · Cell Cycle · doi:10.4161/cc.8.21.9888 · Cited by 468
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Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Ras Conformational Ensembles, Allostery, and Signaling
Lu, S., Jang, H., Muratcioglu, S., Gursoy, A., Keskin, O., Nussinov, R., & Zhang, J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00542 · Cited by 355
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes
Wei, X., Song, H., Yin, L., Rizzo, M. G., Sidhu, R., Covey, D. F., Ory, D. S., & Semenkovich, C. F. (2016) · Nature · doi:10.1038/nature20117 · Cited by 317
Levin, M., Pezzulo, G., & Finkelstein, J. M. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071114-040647 · Cited by 287
Metadata
- Authors
- Zhou, Y., Wong, C.-O., Cho, K.-J., van der Hoeven, D., Liang, H., Thakur, D. P., Luo, J., Babic, M., Zinsmaier, K. E., Zhu, M. X., Hu, H., Venkatachalam, K., & Hancock, J. F.
- Venue
- Science
- Published
- 2015-08-21
- Volume
- 349
- Issue
- 6250
- Pages
- 873-876
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1774371590
- Cited by
- 313
- References
- 1
- FWCI
- 13.51
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Zhou, Y., Wong, C.-O., Cho, K.-J., van der Hoeven, D., Liang, H., Thakur, D. P., Luo, J., Babic, M., Zinsmaier, K. E., Zhu, M. X., Hu, H., Venkatachalam, K., & Hancock, J. F. (2015). Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Science. https://doi.org/10.1126/science.aaa5619
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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