Phthalimide conjugation as a strategy for in vivo target protein degradation
Winter, Georg E., Buckley, Dennis L., Paulk, Joshiawa, Roberts, Justin M., Souza, Amanda, Dhe-Paganon, Sirano, Bradner, James E.·2015·Science
Cited by (1,004)
Items 601–700 of 1,004
- Discovery of BWA-522 , a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate CancerBowen Zhang, Chang Liu, Zhenqian Yang, Sai Zhang, Xiaolin Hu, Baohu Li, Mei Mao, Xiao Wang, Zhuoyue Li, Shumin Ma et al. · 2023 · Journal of Medicinal Chemistry
- Click chemistry in the development of PROTACsCe Yang, Ravi S. Tripathi, Binghe Wang · 2023 · RSC Chemical Biology
- The cyclimids: Degron-inspired cereblon binders for targeted protein degradationSaki Ichikawa, N. Connor Payne, Wenqing Xu, Chia‐Fu Chang, Nandini Vallavoju, Spencer Frome, Hope A. Flaxman, Ralph Mazitschek, Christina M. Woo · 2024 · Cell chemical biology
- Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibitionAndrew C. Runcie, Michael Zengerle, Kwok-Ho Chan, A. Testa, L. van Beurden, Matthias G. J. Baud, Ola Epemolu, Lucy C.J. Ellis, Kevin D. Read, V. Coulthard et al. · 2018 · Chemical Science
- Protein stability and degradation in health and diseaseLene Clausen, Amanda B. Abildgaard, Sarah K. Gersing, Amelie Stein, Kresten Lindorff‐Larsen, Rasmus Hartmann‐Petersen · 2018 · Advances in protein chemistry and structural biology
- Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding SitesMichael D. Olp, Daniel J. Sprague, Christopher J. Goetz, Stefan G. Kathman, Sarah L. Wynia‐Smith, Shifali Shishodia, Steven B. Summers, Ziyang Xu, Alexander V. Statsyuk, Brian C. Smith · 2020 · ACS Chemical Biology
- The therapeutic potential of PROTACsAndrew B. Benowitz, Katherine L. Jones, John D. Harling · 2020 · Expert Opinion on Therapeutic Patents
- CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle–Dependent Degradation of CDK2Kristin M. Riching, Marie K. Schwinn, James D. Vasta, Matthew B. Robers, Thomas Machleidt, Marjeta Urh, Danette L. Daniels · 2020 · SLAS DISCOVERY
- AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing lossSantanu Hati, Marisa Zallocchi, Robert A. Hazlitt, Yuju Li, Sarath Vijayakumar, Jaeki Min, Zoran Ranković, Sándor Lovas, Jian Zuo · 2021 · European Journal of Medicinal Chemistry
- Selectivity through Targeted Protein Degradation (TPD)Ariamala Gopalsamy · 2022 · Journal of Medicinal Chemistry
- Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and BeyondShyaron Poudel, Andrew D. Huber, Taosheng Chen · 2022 · Drug Metabolism and Disposition
- Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer TreatmentJie Zhang, Yuqi Gao, Zipeng Zhang, Jinbo Zhao, Wenshuang Jia, Chengcai Xia, Fugang Wang, Tingting Liu · 2022 · Journal of Medicinal Chemistry
- BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal MyogenesisThomas C. Roberts, Usue Etxaniz, Alessandra Dall’Agnese, Shwu-Yuan Wu, Cheng‐Ming Chiang, Paul E. Brennan, Matthew J. A. Wood, Prem Puri · 2017 · Scientific Reports
- Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancersMarkus Schick, Stefan Habringer, Jonas A. Nilsson, Ulrich Bernd Keller · 2017 · British Journal of Haematology
- The c‐MYC–BMI1 axis is essential for SETDB1‐mediated breast tumourigenesisJin‐Fen Xiao, Qiao‐Yang Sun, Ling‐Wen Ding, Wenwen Chien, Xinyu Liu, Anand Mayakonda, Yan‐Yi Jiang, Xin-Yi Loh, Xue‐Bin Ran, Ngan Doan et al. · 2018 · The Journal of Pathology
- Biology and Therapy of Dominant Fusion Oncoproteins Involving Transcription Factor and Chromatin Regulators in SarcomasJennifer A. Perry, Bo Kyung A. Seong, Kimberly Stegmaier · 2018 · Annual Review of Cancer Biology
- Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinationsSu Lin Lim, Alisa Damnernsawad, Pavithra Shyamsunder, Wee Joo Chng, Bing Han, Liang Xu, Jian Pan, Pushkar Dakle, Serhan Alkan, Jeffrey W Tyner et al. · 2019 · Haematologica
- Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myelomaYan Y. Song, Paul M.C. Park, Lei Wu, Arghya Ray, S. Picaud, Deyao Li, Virangika K. Wimalasena, Ting Du, P. Filippakopoulos, Kenneth Carl Anderson et al. · 2019 · Leukemia
- The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)Neelu Batra, Cristabelle De Souza, Jyoti Batra, Alan G. Raetz, Ai‐Ming Yu · 2020 · International Journal of Molecular Sciences
- Bifunctional HDAC Therapeutics: One Drug to Rule Them All?Joshua P. Smalley, Shaun M. Cowley, James T. Hodgkinson · 2020 · Molecules
- Small-Molecule Approaches to Targeted Protein DegradationTyler B. Faust, Katherine A. Donovan, Hong Yue, Philip P. Chamberlain, Eric S. Fischer · 2020 · Annual Review of Cancer Biology
- USP15 antagonizes CRL4 CRBN -mediated ubiquitylation of glutamine synthetase and neosubstratesThang Van Nguyen · 2021 · Proceedings of the National Academy of Sciences
- An update of label-free protein target identification methods for natural active productsZhao Cui, Caifeng Li, Peng Chen, Hongjun Yang · 2022 · Theranostics
- Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targetingJerry Li, Nicholas Purser, Joanna Liwocha, Daniel C. Scott, Holly A. Byers, Barbara A. Steigenberger, Spencer Hill, Ishita Tripathi‐Giesgen, Trent B. Hinkle, Fynn M. Hansen et al. · 2024 · Molecular Cell
- Degradation of Akt using protein-catalyzed capture agentsRyan K. Henning, Joseph O. Varghese, Samir Das, Arundhati Nag, Grace Y. Tang, Kevin Tang, Alexander M. Sutherland, James R. Heath · 2016 · Journal of Peptide Science
- Targeted protein degradation mechanismsYi Zhang, Christine Loh, Jesse Chen, Nello Mainolfi · 2019 · Drug Discovery Today Technologies
- Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets.Seonghyeon Moon, Byung‐Hoon Lee · 2018 · Europe PMC (PubMed Central)
- Development of a PDEδ‐Targeting PROTACs that Impair Lipid MetabolismMichael Winzker, Alexandra Friese, Uwe Koch, Petra Janning, Slava Ziegler, Herbert Waldmann · 2019 · Angewandte Chemie International Edition
- Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC)Zhenzhen Li, Siyue Ma, Xingye Yang, Ling Zhang, Liang Dong, Gaopan Dong, Lüpei Du, Zhenghua Lv, Minyong Li · 2021 · European Journal of Medicinal Chemistry
- A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degraderPayne, N. Connor, Maksoud, Semer, Tannous, Bakhos A., Mazitschek, Ralph · 2022 · Cell Chemical Biology
- Targeted Protein Degradation to Overcome Resistance in Cancer Therapies: PROTAC and N-Degron PathwayHanbyeol Kim, Jeongbae Park, Jeong‐Mok Kim · 2022 · Biomedicines
- Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivativesRadosław P. Nowak, Jianwei Che, Silas Ferrao, Nikki R. Kong, Hu Liu, Breanna L. Zerfas, Lyn H. Jones · 2023 · RSC Medicinal Chemistry
- Deregulated transcription factors in the emerging cancer hallmarksAdria Hasan, Naushad Ahmad Khan, Shahab Uddin M.S., Abdul Q. Khan, Martin S. Steinhoff · 2023 · Seminars in Cancer Biology
- Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligasesJoanna Liwocha, Jerry Li, Nicholas Purser, Chutima Rattanasopa, Samuel A. Maiwald, David T. Krist, Daniel C. Scott, Barbara A. Steigenberger, Jesuraj Rajan Prabu, Brenda Arlene Schulman et al. · 2024 · Nature Structural & Molecular Biology
- Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin LigaseXavier Lucas, Inge Van Molle, Alessio Ciulli · 2018 · Journal of Medicinal Chemistry
- Aberrant Activation of NF-κB Signalling in Aggressive Lymphoid MalignanciesRuth Kennedy, Ulf Klein · 2018 · Cells
- Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradationHong Chen, Feihong Chen, Sinan Pei, Shaohua Gou · 2019 · Bioorganic Chemistry
- Monitoring protein communities and their responses to therapeuticsHanna G. Budayeva, Donald S. Kirkpatrick · 2020 · Nature Reviews Drug Discovery
- The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3LBingbing Hao, Xiaojing Li, Xinglong Jia, Yuxing Wang, Linhui Zhai, Duanzhuo Li, Jie Liu, Die Zhang, Yu-Lu Chen, Yonghu Xu et al. · 2020 · Acta Pharmacologica Sinica
- Advances and perspectives of proteolysis targeting chimeras (PROTACs) in drug discoveryJiayue Xi, Ruyue Zhang, Ke Chen, Lin Yao, Muqiong Li, Ru Jiang, Xiaoye Li, Li Fan · 2022 · Bioorganic Chemistry
- Targeted Degradation of the Oncogenic Phosphatase SHP2Vemulapalli, Vidyasiri, Donovan, Katherine A., Seegar, Tom C. M., Rogers, Julia M., Bae, Munhyung, Lumpkin, Ryan J., Cao, Ruili, Henke, Matthew T., Ray, Soumya S., Fischer, Eric S. et al. · 2021 · Biochemistry
- Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platformsGrohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S. et al. · 2022 · Nature Communications
- Ligation to Scavenging Strategy Enables On-Demand Termination of Targeted Protein DegradationYuhui Jin, Jing Fan, Ruyan Wang, Xuanyu Wang, Ning Li, Qidong You, Zhengyu Jiang · 2023 · Journal of the American Chemical Society
- The application of PROTAC in HDACShaoting Chen, Yuxiang Zheng, Benji Liang, Yudong Yin, Jian Yao, Quande Wang, Yanghan Liu, Nouri Neamati · 2023 · European Journal of Medicinal Chemistry
- Proteolysis Targeting Chimera Degraders of the METTL3–14 m 6 A-RNA MethyltransferaseFrancesco Errani, Annalisa Invernizzi, Marcin Herok, Elena Bochenkova, Fiona Stamm, Ivan Corbeski, Valeria Romanucci, Giovanni Di Fabio, František Zálešák, Amedeo Caflisch · 2024 · JACS Au
- Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradationChrysanthi Kagiou, Jose Antonio Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin D. Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer et al. · 2024 · Nature Communications
- Small molecules as tools to study the chemical epigenetics of lysine acetylationMatthias Schiedel, Stuart J. Conway · 2018 · Current Opinion in Chemical Biology
- N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Spiro-glutarimides via α,β-Unsaturated AcylazoliumsSantigopal Mondal, Arghya Ghosh, Subrata Mukherjee, Akkattu T. Biju · 2018 · Organic Letters
- Pharmacological Targeting of BET Bromodomain Proteins in Acute Myeloid Leukemia and Malignant Lymphomas: From Molecular Characterization to Clinical ApplicationsDiana Reyes-Garau, Marcelo Lima Ribeiro, Gaël Roué · 2019 · Cancers
- Development of cell-permeable peptide-based PROTACs targeting estrogen receptor αYuxuan Dai, Yue Na, Junni Gong, Chunxia Liu, Qifei Li, Jiaqi Zhou, Wenlong Huang, Hai Qian · 2019 · European Journal of Medicinal Chemistry
- Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical LibrariesOlivier B. C. Monty, Pranavanand Nyshadham, Kurt M. Bohren, Murugesan Palaniappan, Martin Matthew Matzuk, Damian W. Young, Nicholas Simmons · 2020 · ACS Combinatorial Science
- PROTACs: New method to degrade transcription regulating proteinsBei-Chen Hu, Yirong Zhou, Dejuan Sun, Yueying Yang, Yang Liu, Xingzhou Li, Hua Li, Lixia Chen · 2020 · European Journal of Medicinal Chemistry
- Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic DrugsDong‐Dong Li, Pan Yu, Wei Xiao, Zhenzhong Wang, Lin-Guo Zhao · 2020 · Current Topics in Medicinal Chemistry
- Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutationLiang Jiang, Yuting Wang, Qian Li, Zhengchao Tu, Sihua Zhu, Sanfang Tu, Zhang Zhang, Ke Ding, Xiaoyun Lu · 2020 · Acta Pharmaceutica Sinica B
- Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the WayWei Li, Hao Wu, Shiyao Sui, Qin Wang, Shouping Xu, Da Pang · 2021 · Frontiers in Cell and Developmental Biology
- Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship StudiesXufen Yu, Jia Xu, Yudao Shen, Kaitlyn M. Cahuzac, Kwang‐Su Park, Brandon Dale, Jing Liu, Ramon E. Parsons, Jian Jun Jin · 2022 · Journal of Medicinal Chemistry
- Development of Photolenalidomide for Cellular Target IdentificationZhi Lin, Yuka Amako, Farah Kabir, Hope A. Flaxman, Bogdan Budnik, Christina M. Woo · 2022 · Journal of the American Chemical Society
- Inducing Protein Degradation as a Therapeutic StrategyCraig M. Crews · 2017 · Journal of Medicinal Chemistry
- Development of inhibitors targeting glycogen synthase kinase-3β for human diseases: Strategies to improve selectivityWei, Junxia, Wang, Jiaxing, Zhang, Jifa, Yang, Jinliang, Wang, Guan, Wang, Yuxi · 2022 · European Journal of Medicinal Chemistry
- PROTACS: A technology with a gold rush-like atmosphereYuwei Wang, Li Lan, Min Wang, Jinyang Zhang, Yuhui Gao, Lei Shi, Li‐Ping Sun · 2022 · European Journal of Medicinal Chemistry
- Progress in the controllability technology of PROTACXin Wen He, Zhibing Weng, Yi Zou · 2023 · European Journal of Medicinal Chemistry
- Degraders in epigenetic therapy: PROTACs and beyondXing‐Jie Dai, Shi‐Kun Ji, Meng‐Jie Fu, Gao-Zhi Liu, Huimin Liu, Shaopeng Wang, Liang Shen, Ning Wang, Piet A. Herdewijn, Yi‐Chao Zheng et al. · 2024 · Theranostics
- Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer DrugsRohan Kalyan Rej, Srinivasa Rao Allu, Joyeeta Roy, Ranjan Kumar Acharyya, I. N. Chaithanya Kiran, Yesu Addepalli, V. Dhamodharan · 2024 · Pharmaceuticals
- Induced proximity-based therapeutic modalitiesElizabeth A. King, Margot Meyers, Daniel K. Nomura · 2025 · Nature Reviews Drug Discovery
- Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applicationsChen Ma, Junkai Cheng, Jian Hong Gu, Qin Wang · 2025 · Molecular Biomedicine
- Targeting Histone AcetylationChristopher Brent Benton, Warren C. Fiskus, Kapil N. Bhalla · 2017 · The Cancer Journal
- New Drugs in Multiple MyelomaChutima Kunacheewa, Robert Zygmunt Orlowski · 2019 · Annual Review of Medicine
- Development and biological applications of sulfur–triazole exchange (SuTEx) chemistryAdam L. Borne, Jeffrey W. Brulet, Kun Yuan, Ku‐Lung Hsu · 2021 · RSC Chemical Biology
- Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degradersNisha Setia, Haider Thaer Abdulhameed Almuqdadi, Mohammad Abid · 2023 · European Journal of Medicinal Chemistry
- Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC developmentJasmin Lohbeck, Aubry K. Miller · 2016 · Bioorganic & Medicinal Chemistry Letters
- Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligaseWei-Wei Kung, Sarath Ramachandran, Nikolai Makukhin, Elvira Bruno, Alessio Ciulli · 2019 · Nature Communications
- Identification and selectivity profiling of small-molecule degraders via multi-omics approachesNatalie S. Scholes, Cristina Mayor‐Ruiz, Georg E. Winter · 2021 · Cell chemical biology
- Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent KinaseSandeep Rana, Jayapal Reddy Mallareddy, Sarbjit Singh, Lidia Boghean, Amarnath Natarajan · 2021 · Cancers
- Recent advances in targeted protein degraders as potential therapeutic agentsNa Yang, Bo Kong, Zhaohong Zhu, Fei Huang, Liliang Zhang, Tao Lu, Yadong Chen, Yanmin Zhang, Yulei Jiang · 2023 · Molecular Diversity
- Niedermolekulare PROTACs: neue Wege zum Abbau von ProteinenToure, Momar, Crews, Craig M. · 2016 · Angewandte Chemie
- Cereblon-Recruiting PROTACs: Will New Drugs Have to Face Old Challenges?Marcin Cieślak, Marta Słowianek · 2023 · Pharmaceutics
- Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists?Anna Pasieka, Eleonora Diamanti, Elisa Uliassi, María Laura Bolognesi · 2023 · ChemMedChem
- Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from LatencyRoberto Alfonso, Anne‐Marie W. Turner, Pierre M. Jean Beltran, Jesse H. Arbuckle, Hanna G. Budayeva, Ileana M. Cristea, Thomas M. Kristie · 2017 · Cell Host & Microbe
- Neue Modalitäten für schwierige Zielstrukturen in der WirkstoffentwicklungEric Valeur, Stéphanie M. Guéret, Hélène Adihou, Ranganath Gopalakrishnan, Malin Lemurell, Herbert Waldmann, Tom N. Grossmann, Alleyn T. Plowright · 2017 · Angewandte Chemie
- Phosphine‐Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylationJoshua S. Wesalo, Ji Luo, Kunihiko Morihiro, Jihe Liu, Alexander Deiters · 2019 · ChemBioChem
- Native Mass Spectrometry for the Study of PROTAC GNE‐987‐Containing Ternary ComplexesLouise M. Sternicki, Jim Nonomiya, Miaomiao Liu, Melinda M. Mulvihill, Ronald J. Quinn · 2021 · ChemMedChem
- Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome ProfileChaowei Ren, Ning Sun, Haixia Liu, Ying Kong, Renhong Sun, Xing Qiu, Jinju Chen, Yan Li, Jianshui Zhang, Yuedong Zhou et al. · 2021 · Journal of Medicinal Chemistry
- Controlling PROTACs with LightShreya Verma, Debasish Manna · 2020 · ChemMedChem
- Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategySong Chen, Zhendong Chen, Lixue Lu, Yunpeng Zhao, Ronghui Zhou, Qiong Xie, Yongzhi Shu, Jun Lin, Xufen Yu, Yonghui Wang · 2023 · European Journal of Medicinal Chemistry
- Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal TraffickingPriyanka Mangla, Quentin Vicentini, Annabelle Biscans · 2023 · Cells
- Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1Margot Meyers, Sabine Cismoski, Anoohya Panidapu, Barbara Chie-Leon, Daniel K. Nomura · 2024 · ACS Chemical Biology
- Targeting the Undruggable: Recent Progress in PROTAC-Induced Transcription Factor DegradationHyein Jung, Yeongju Lee · 2025 · Cancers
- Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future DirectionsGang Fan, Shilin Chen, Qingping Zhang, Na Yu, Ziyang Shen, Zhaoji Liu, Weiming Guo, Zhi‐Han Tang, Jing Yang, Miao Liu · 2025 · MedComm
- Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunitiesMatthew J. McBride, Cigall Kadoch · 2018 · The Journal of Pathology
- Chemical Protein Degradation Approach and its Application to Epigenetic TargetsYukihiro Itoh · 2018 · The Chemical Record
- Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulasYu Wang, Yan‐Jiao Chen, Cheng Xiang, Guang-Wei Jiang, Yu‐Dong Xu, Lei-Miao Yin, Dongdong Zhou, Yanyan Liu, Yong‐Qing Yang · 2020 · Journal of Ethnopharmacology
- Traceless Staudinger ligation enabled parallel synthesis of proteolysis targeting chimera linker variantsTroy A. Bemis, James J. La Clair, Michael D. Burkart · 2020 · Chemical Communications
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanismJie Li, Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi‐Hsuan Tsai, Xufen Yu, Jeong Hyun Ahn, Yiran Guo, Samuel G. Mackintosh, Ricky D. Edmondson et al. · 2021 · Nature Communications
- PROTACs, molecular glues and bifunctionals from bench to bedside: Unlocking the clinical potential of catalytic drugsMarı́a Maneiro, Elena De Vita, Daniel Conole, Cyrille S. Kounde, Qisi Zhang, Edward W. Tate · 2021 · Progress in medicinal chemistry
- Is PROTAC technology really a game changer for central nervous system drug discovery?Kayla Farrell, Timothy J. Jarome · 2021 · Expert Opinion on Drug Discovery
- Identification and validation of selective deubiquitinase inhibitorsAnthony C. Varca, Dominick E. Casalena, Wai Cheung Chan, Bin Hu, Robert S. Magin, Rebekka M. Roberts, Xiaoxi Liu, He Zhu, Hyuk‐Soo Seo, Sirano Dhe‐Paganon et al. · 2021 · Cell chemical biology
- Options to Improve the Action of PROTACs in Cancer: Development of Controlled Delivery NanoparticlesAlberto Juan, María del Mar Noblejas‐López, María Arenas-Moreira, Carlos Alonso‐Moreno, Alberto Ocaña · 2022 · Frontiers in Cell and Developmental Biology
- Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against CancerJia‐Yi Lin, Haijun Liu, Ye Wu, Jin‐Mei Jin, Yudong Zhou, Hong Zhang, Dale G. Nagle, Hongzhuan Chen, Weidong Zhang, Xin Luan · 2023 · Small
- PROTACs in Epigenetic Cancer Therapy: Current Status and Future OpportunitiesXuelian Liu, Anjin Wang, Yuying Shi, Mengyuan Dai, Miao Liu, Hongbing Cai · 2023 · Molecules
- Targeting bromodomain-containing proteins: research advances of drug discoveryZhaoping Pan, Yuxi Zhao, Xiaoyun Wang, Xin Xie, Mingxia Liu, Kaiyao Zhang, Lian Wang, Ding Bai, Leonard J. Foster, Rui Shu et al. · 2023 · Molecular Biomedicine