The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys
Open accessAbstract
To defeat SIV, add a protein boost: Despite 30 years of effort, no HIV-1 vaccine exists. Barouch et al. evaluated one promising strategy in rhesus macaques, a preclinical model commonly used to test potential HIV-1 vaccine candidates. They immunized monkeys with adenovirus-36 vectors engineered to express SIV (simian immunodeficiency virus) genes and then boosted them with a recombinant gp120 envelope glycoprotein (Env) from SIV. This regimen afforded greater protection than a strategy that instead used a viral vector–based boost. A parallel trial using a SHIV (simian/human immunodeficiency virus)–based vaccine and challenge model produced similar results. Whether this particular approach will be equally successful in humans remains to be tested. Science , this issue p. 320
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Self-citationEfficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine
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Self-citationEvaluating Neutralizing Antibodies Against HIV, SIV, and SHIV in Luciferase Reporter Gene Assays
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Atyeo, C., Fischinger, S., Zohar, T., Slein, M. D., Burke, J., Loos, C., McCulloch, D. J., Newman, K. L., Wolf, C., Yu, J., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.020 · Cited by 349
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Self-citationShangguan, S., Ehrenberg, P. K., Geretz, A., Yum, L., Kundu, G., May, K., Fourati, S., Nganou-Makamdop, K., Williams, L. D., Sawant, S., et al. (2021) · eLife · doi:10.7554/elife.69577 · Cited by 26
Metadata
- Authors
- Barouch, D. H., Alter, G., Broge, T., Linde, C., Ackerman, M. E., Brown, E. P., Borducchi, E. N., Smith, K. M., Nkolola, J. P., Liu, J., Shields, J., Parenteau, L., Whitney, J. B., Abbink, P., Ng’ang’a, D. M., Seaman, M. S., Lavine, C. L., Perry, J. R., Li, W., Colantonio, A. D., Lewis, M. G., Chen, B., Wenschuh, H., Reimer, U., Piatak, M., Lifson, J. D., Handley, S. A., Virgin, H. W., Koutsoukos, M., Lorin, C., Voss, G., Weijtens, M., Pau, M. G., & Schuitemaker, H.
- Venue
- Science
- Published
- 2015-07-17
- Volume
- 349
- Issue
- 6245
- Pages
- 320-324
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1656961899
- Cited by
- 297
- References
- 34
- FWCI
- 22.52
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Barouch, D. H., Alter, G., Broge, T., Linde, C., Ackerman, M. E., Brown, E. P., Borducchi, E. N., Smith, K. M., Nkolola, J. P., Liu, J., Shields, J., Parenteau, L., Whitney, J. B., Abbink, P., Ng’ang’a, D. M., Seaman, M. S., Lavine, C. L., Perry, J. R., Li, W., . . . Schuitemaker, H. (2015). Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Science. https://doi.org/10.1126/science.aab3886
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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