The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples
Open accessAbstract
Estimating bacterial growth dynamics: The pattern of sequencing read coverage of bacteria in metagenomic samples reflects the growth rate. This pattern is predictive of growth because bacterial genomes are circular, with a single origin of replication. So during growth, copies of the genome accumulate at the origin. Korem et al. use the ratio of copy number at the origin to the copy number at the terminus to detect the actively growing species in a microbiome (see the Perspective by Segre). They could spot the difference between virulent and avirulent strains, population diurnal oscillations, species that are growing in irritable bowel disease, and what happens when a host's diet changes. Results were consistent in chemostats, in mice, and in human fecal samples. Science , this issue p. 1101 ; see also p. 1058
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Cites
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Self-citationBiogeography and individuality shape function in the human skin metagenome
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Gut microbiota in human metabolic health and disease
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Personalized nutrition by prediction of glycemic responses
Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., Ben-Yacov, O., Lador, D., Avnit-Sagi, T., Lotan-Pompan, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.001 · Cited by 2,929
Self-citationByrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Shotgun metagenomics, from sampling to analysis
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Best practices for analysing microbiomes
Knight, R., Vrbanac, A., Taylor, B. C., Aksenov, A., Callewaert, C., Debelius, J., Gonzalez, A., Kosciolek, T., McCall, L.-I., McDonald, D., et al. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0029-9 · Cited by 2,030
Metadata
- Authors
- Korem, T., Zeevi, D., Suez, J., Weinberger, A., Avnit-Sagi, T., Pompan-Lotan, M., Matot, E., Jona, G., Harmelin, A., Cohen, N., Sirota-Madi, A., Thaiss, C. A., Pevsner-Fischer, M., Sorek, R., Xavier, R. J., Elinav, E., & Segal, E.
- Venue
- Science
- Published
- 2015-09-04
- Volume
- 349
- Issue
- 6252
- Pages
- 1101-1106
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2141137078
- Cited by
- 446
- References
- 10
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Korem, T., Zeevi, D., Suez, J., Weinberger, A., Avnit-Sagi, T., Pompan-Lotan, M., Matot, E., Jona, G., Harmelin, A., Cohen, N., Sirota-Madi, A., Thaiss, C. A., Pevsner-Fischer, M., Sorek, R., Xavier, R. J., Elinav, E., & Segal, E. (2015). Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples. Science. https://doi.org/10.1126/science.aac4812
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