Cited by 46Advanced Glycation End Products researchCarbohydrate Chemistry and SynthesisSynthesis and Reactions of Organic Compounds

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Concise total synthesis of glucosepane

Abstract

Getting a handle on a cross-linking motif: Although protein backbones consist exclusively of amino acids, various other molecules in the cell often get latched on afterward in a process termed posttranslational modification. In one such motif, called glucosepane, the side chains of lysine and arginine form a condensed cross-link through a reaction sequence with glucose. Formation of this cross-link is of interest in diabetes research. Draghici et al. now report a chemical synthesis of glucosepane outside the broader environment of a surrounding protein (see the Perspective by Boger). This synthesis should facilitate more precise characterization of the structure and function of the motif in vivo. Science , this issue p. 294 ; see also p. 275

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Crossref · 10.1126/science.aac9655

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Metadata

Authors
Draghici, C., Wang, T., & Spiegel, D. A.
Affiliations
Yale University (US)
Corresponding author
Spiegel, David A.
Venue
Science
Published
2015-10-16
Volume
350
Issue
6258
Pages
294-298
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2279983270
Cited by
46
References
28
Citations by year
2026: 2 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 1
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
SENS Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and Reactions of Organic Compounds
Keywords
glucosepane, total synthesis, protein posttranslational modification, one-pot synthesis, asymmetric synthesis, convergent synthesis, heterocyclic chemistry, diabetes mellitus, aging
MeSH terms
Amino Acids, Glucose, Humans, Imidazoles, Protein Processing, Post-Translational, Proteins, Glycation End Products, Advanced

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