CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Bidinosti, Michael, Botta, Paolo, Krüttner, Sebastian, Proenca, Catia C., Stoehr, Natacha, Bernhard, Mario, Fruh, Isabelle, Mueller, Matthias +12 more·2016·Science
DOI 10.1126/science.aad5487

Cited by (152)

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  11. Elevation of SHANK3 Levels by Antisense Oligonucleotides Directed Against the 3′-UTR of the Human SHANK3 mRNA
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  12. Pharmacological modulation of developmental and synaptic phenotypes in human SHANK3 deficient stem cell-derived neuronal models
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  14. Modelling Autistic Neurons with Induced Pluripotent Stem Cells
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  15. Autism-associated Shank3 is essential for homeostatic plasticity and neuronal circuit stability
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  18. A Frank Assessment of SHANK : Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome
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  20. Unraveling a pathway to autism
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  24. Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation
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  26. Using iPSC-Based Models to Understand the Signaling and Cellular Phenotypes in Idiopathic Autism and 16p11.2 Derived Neurons
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  27. An N‐terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice
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  29. Intracellular Pathways Associated with the Etiology of Autism
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  30. Rescue strategy
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  31. AUTS2 gene dosage affects synaptic AMPA receptors via a local dendritic spine AUTS2-TTC3-AKT-mTORC1 signaling dysfunction
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  32. Proteína CLK2 (Cdc-2-like kinase 2) no hipotálamo é importante para a manutenção da homeostase energética
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  33. The Use of Synaptosomes in Studying Autism Spectrum Disorder and Other Neurodevelopmental Disorders
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  34. Calculating the Effects of Autism Risk Gene Variants on Dysfunction of Biological Processes Identifies Clinically-Useful Information
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  35. Сигнальные каскады белкового фосфорилирования при аутизме (с акцентом на путь mTOR)
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  45. Activité hippocampique associée aux stimuli sociaux chez la souris Shank3 modèle des Troubles du Spectre Autistique.
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  51. BindingDB Entry 50021297: Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis.
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