The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Airway acidification initiates host defense abnormalities in cystic fibrosis mice
Open accessAbstract
Airway infections put to an acid test: Most people with cystic fibrosis suffer from chronic respiratory infections. The mechanistic link between this symptom and the genetic cause of the disease (mutations that compromise the function of the cystic fibrosis transmembrane conductance regulator, CFTR) is not fully understood. Studying animal models, Shah et al. find that in the absence of functional CFTR, the surface liquid in the airways becomes acidic, which impairs host defenses against infection. This acidification occurs through the action of a proton pump called ATP12A. Molecules inhibiting ATP12A could potentially be developed into useful drugs. Science , this issue p. 503
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Submucosal glands and airway defense
Wine, J. J., & Joo, N. S. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.2306015 · Cited by 223
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Montoro, D. T., Haber, A. L., Biton, M., Vinarsky, V., Lin, B., Birket, S. E., Yuan, F., Chen, S., Leung, H. M., Villoria, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0393-7 · Cited by 1,206
A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte
Plasschaert, L. W., Žilionis, R., Choo-Wing, R., Savova, V., Knehr, J., Roma, G., Klein, A. M., & Jaffe, A. B. (2018) · Nature · doi:10.1038/s41586-018-0394-6 · Cited by 1,047
Pseudomonas aeruginosa Biofilms: Host Response and Clinical Implications in Lung Infections
Maurice, N. M., Bedi, B., & Sadikot, R. T. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0321tr · Cited by 373
Structure, Gating, and Regulation of the CFTR Anion Channel
Csanády, L., Vergani, P., & Gadsby, D. C. (2019) · Physiological Reviews · doi:10.1152/physrev.00007.2018 · Cited by 262
Genetic medicines for CF: Hype versus reality
Alton, E. W. F. W., Boyd, A. C., Davies, J. C., Gill, D. R., Griesenbach, U., Harrison, P. T., Henig, N., Higgins, T., Hyde, S. C., Innes, J. A., et al. (2016) · Pediatric Pulmonology · doi:10.1002/ppul.23543 · Cited by 53
Metadata
- Authors
- Shah, V. S., Meyerholz, D. K., Tang, X. X., Reznikov, L., Abou Alaiwa, M., Ernst, S. E., Karp, P. H., Wohlford-Lenane, C. L., Heilmann, K. P., Leidinger, M. R., Allen, P. D., Zabner, J., McCray, P. B., Ostedgaard, L. S., Stoltz, D. A., Randak, C. O., & Welsh, M. J.
- Venue
- Science
- Published
- 2016-01-29
- Volume
- 351
- Issue
- 6272
- Pages
- 503-507
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2270680140
- Cited by
- 291
- References
- 1
- FWCI
- 35.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Shah, V. S., Meyerholz, D. K., Tang, X. X., Reznikov, L., Abou Alaiwa, M., Ernst, S. E., Karp, P. H., Wohlford-Lenane, C. L., Heilmann, K. P., Leidinger, M. R., Allen, P. D., Zabner, J., McCray, P. B., Ostedgaard, L. S., Stoltz, D. A., Randak, C. O., & Welsh, M. J. (2016). Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science. https://doi.org/10.1126/science.aad5589
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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