Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism
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- The importance of Ras in drug resistance in cancerFiona M. Healy, Ian A. Prior, David J. MacEwan · 2021 · British Journal of Pharmacology
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- Pharmacological restoration of GTP hydrolysis by mutant RASAntonio Cuevas-Navarro, Yasin Pourfarjam, Feng Hu, Diego J. Rodriguez, Alberto Vides, Ben Sang, Shijie Fan, Yehuda Goldgur, Elisa de Stanchina, Piro Lito · 2024 · Nature
- Biological therapies in nonsmall cell lung cancerJon Zugazagoitia, Sonia Molina‐Pinelo, Fernando López‐Ríos, Luis G Paz-Ares · 2017 · European Respiratory Journal
- A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung CancersStephanie L. Guerra, Ophélia Maertens, Ryan Kuzmickas, Thomas De Raedt, Richard O. Adeyemi, Caroline J. Guild, Shawna Guillemette, Amanda J. Redig, Emily S. Chambers, Man Xu et al. · 2020 · Cancer Cell
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- Irreversibility in dynamical phases and transitionsDaniel S. Seara, Benjamin B. Machta, Michael P. Murrell · 2021 · Nature Communications
- KRAS-dependent cancer cells promote survival by producing exosomes enriched in SurvivinWen-Hsuan Chang, Thuy‐Tien T. Nguyen, Chia‐Hsin Hsu, Kirsten L. Bryant, Hong Jin Kim, Haoqiang Ying, Jon W. Erickson, Channing J. Der, Richard A. Cerione, Marc A. Antonyak · 2021 · Cancer Letters
- Targeting KRAS mutant lung cancer: light at the end of the tunnelMatthias Drosten, Mariano Barbacid · 2021 · Molecular Oncology
- Targeting KRAS G12C Mutation in Colorectal Cancer, A Review: New Arrows in the QuiverJavier Ros, Caterina Vaghi, Iosune Baraibar, Nadia Saoudi Gonzalez, Marta Rodríguez-Castells, Ariadna García, Adriana Alcaráz, Francesc Salvà, Josep M. Tabernero, Elena Élez · 2024 · International Journal of Molecular Sciences
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- Next-generation therapies for pancreatic cancerConor W. Buckley, Eileen Mary O'Reilly · 2024 · Expert Review of Gastroenterology & Hepatology
- Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoformsH Y Lau, Jingyi Tang, Patrick J. Casey, Mei Wang · 2017 · Oncogene
- Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosisMou, Haiwei, Moore, Jill, Malonia, Sunil K., Li, Yingxiang, Ozata, Deniz M., Hough, Soren, Song, Chun-Qing, Smith, Jordan L., Fischer, Andrew, Weng, Zhiping et al. · 2017 · Proceedings of the National Academy of Sciences
- Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant CancersGisele Nishiguchi, Alice C. Rico, Huw R. Tanner, Robert J. Aversa, Benjamin R. Taft, Sharadha Subramanian, L Setti, Matthew T. Burger, Lifeng Wan, Victoriano Tamez et al. · 2017 · Journal of Medicinal Chemistry
- Blocking Ras inhibition as an antitumor strategyNagore I. Marín‐Ramos, Silvia Ortega‐Gutiérrez, María Luz López-Rodríguez · 2018 · Seminars in Cancer Biology
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- Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal MelanomaTyler D. Hitchman, Gabriella Bayshtok, Emilie Ceraudo, Amanda R. Moore, Cindy Lee, Ruobing Jia, Naitao Wang, Mohini R. Pachai, Alexander Noor Shoushtari, Jasmine H. Francis et al. · 2020 · Clinical Cancer Research
- A FAM83A Positive Feed-back Loop Drives Survival and Tumorigenicity of Pancreatic Ductal AdenocarcinomasNeetha Parameswaran, Courtney A. Bartel, Wilnelly M. Hernandez-Sanchez, Kristy L. S. Miskimen, Jacob M. Smigiel, Ahmad Mohammad Khalil, Mark W. Jackson · 2019 · Scientific Reports
- Clinical and Genomic Features of Response and Toxicity to Sotorasib in a Real-World Cohort of Patients With Advanced KRAS G12C-Mutant Non–Small Cell Lung CancerRohit Thummalapalli, Ezra Bernstein, Benjamin O. Herzberg, Bob T. Li, Afsheen N. Iqbal, Isabel Ruth Preeshagul, Fernando Costa Santini, Juliana Eng, Marc Ladanyi, Soo‐Ryum Yang et al. · 2023 · JCO Precision Oncology
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- Targeting KRAS G12C with Covalent InhibitorsJonathan M. L. Ostrem, Kevan M. Shokat · 2021 · Annual Review of Cancer Biology
- Role of RAS signaling in ovarian cancerLubna Therachiyil, Anjana Anand, Abdullah Azmi, Ajaz Ahmad Bhat, Hesham Mohamed Korashy, Shahab Uddin M.S. · 2022 · F1000Research
- Glutamine Metabolism: Molecular Regulation, Biological Functions, and DiseasesMudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira Al‐Shabeeb Akil, Muzafar Ahmad Macha et al. · 2025 · MedComm
- Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAFWenlin Shao, Yuji M. Mishina, Yunjiang Feng, Giordano Caponigro, Vesselina G. Cooke, Stacy Rivera, Yingyun Wang, Fang Shen, Joshua M. Korn, Lesley A. Mathews Griner et al. · 2018 · Cancer Research
- Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the ClinicSavithri Ramurthy, Benjamin R. Taft, Robert J. Aversa, Paul A. Barsanti, Matthew T. Burger, Yan Chun Lou, Gisele Nishiguchi, Alice C. Rico, L Setti, Aaron Smith et al. · 2019 · Journal of Medicinal Chemistry
- Efforts to Develop KRAS InhibitorsHolderfield, Matthew · 2018 · Cold Spring Harbor Perspectives in Medicine
- Treating KRAS -mutant NSCLC: latest evidence and clinical consequencesPilar Garrido, Maria Eugenia Olmedo, Ana Gómez, Luis Paz Ares, Fernando López‐Ríos, Juan Manuel Rosa-Rosa, José Palacios · 2017 · Therapeutic Advances in Medical Oncology
- KRAS inhibition in non–small cell lung cancer: Past failures, new findings and upcoming challengesFrancesco Passiglia, Umberto Malapelle, Marzia Del Re, Luisella Righi, Fabio Pagni, Daniela Furlan, Romano Danesi, Giancarlo Troncone, Silvia Novello · 2020 · European Journal of Cancer
- RAS as a positive predictive biomarker: focus on lung and colorectal cancer patientsUmberto Malapelle, Francesco Passiglia, Chiara Cremolini, Maria Lucia Reale, Francesco Pepe, Pasquale Pisapia, Antonio Avallone, Diego Luigi Cortinovis, Alfonso De Stefano, Matteo Fassan et al. · 2021 · European Journal of Cancer
- Current Perspectives and Novel Strategies of NRAS-Mutant MelanomaAlejandro García‐Álvarez, Carolina Ortiz, Eva Muñoz‐Couselo · 2021 · OncoTargets and Therapy
- Glecirasib in KRASG12C-mutated nonsmall-cell lung cancer: a phase 2b trialShi, Yuankai, Fang, Jian, Xing, Ligang, Yao, Yu, Zhang, Jian, Liu, Lian, Wang, Yongsheng, Hu, Changlu, Xiong, Jianping, Liu, Zhihua et al. · 2025 · Nature Medicine
- Heterogeneity and mutation in KRAS and associated oncogenes: evaluating the potential for the evolution of resistance to targeting of KRAS G12CVincent L. Cannataro, Stephen G. Gaffney, Carly Stender, Zi-Ming Zhao, Mark R. Philips, Andrew E. Greenstein, Jeffrey P. Townsend · 2018 · Oncogene
- Precision medicine in pancreatic cancer: treating every patient as an exceptionBrian T. Herbst, Lei Zheng · 2019 · The Lancet. Gastroenterology & hepatology
- Not all RAS mutations are equal: A detailed review of the functional diversity of RAS hot spot mutationsRachel A. Burge, G. Aaron Hobbs · 2022 · Advances in cancer research
- Overcoming adaptive resistance to KRAS inhibitors through vertical pathway targetingYaeger, Rona, Solit, David B. · 2020 · Clinical Cancer Research
- From bench to bedside: current development and emerging trend of KRAS-targeted therapyYi Chen, Qiu-pei Liu, Hua Xie, Jian Ding · 2023 · Acta Pharmacologica Sinica
- Resistance to KRAS G12C Inhibition in Non-small Cell Lung CancerAlessandro Di Federico, Ilaria Ricciotti, Valentina Favorito, Sandra Vietti Michelina, Pietro Scaparone, Giulio Metro, Andrea De Giglio, Federica Pecci, Giuseppe Lamberti, Chiara Ambrogio et al. · 2023 · Current Oncology Reports
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- Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer CellsXie, Chun, Li, Ying, Li, Lan-Lan, Fan, Xing-Xing, Wang, Yu-Wei, Wei, Chun-Li, Liu, Liang, Leung, Elaine Lai-Han, Yao, Xiao-Jun · 2017 · Frontiers in Pharmacology
- Genomic testing for pancreatic cancer in clinical practice as real-world evidenceHideyuki Hayashi, Shigeki Tanishima, Kyōkō Fujii, Ryo Mori, Yasunobu Okamura, Emmy Yanagita, Ryosuke Matsuoka, Toraji Amano, Ichiro Kinoshita, Yoshito Komatsu et al. · 2018 · Pancreatology
- KRAS G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung AdenocarcinomaGregory D. Jones, Raul Caso, Kay See Tan, Brooke Mastrogiacomo, Francisco Sánchez-Vega, Yuan Liu, James G. Connolly, Yonina R. Murciano‐Goroff, Matthew Joseph Bott, Prasad S. Adusumilli et al. · 2021 · Clinical Cancer Research
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- D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical ActivitiesJing Zhang, Sun Min Lim, Mi Ra Yu, Cheng Chen, Jia Wang, Wenqian Wang, Haopeng Rui, Jingtao Lu, Shun Lü, Tony S.K. Mok et al. · 2024 · Cancer Discovery
- KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass SpectrometryJia Lu, Rane A. Harrison, Lianbo Li, Mei Zeng, Sudershan Reddy Gondi, David A. Scott, Nathanael S. Gray, John R. Engen, Kenneth D. Westover · 2017 · Structure
- Behind the Wheel of Epithelial Plasticity in KRAS-Driven CancersEmily Nicole Arner, Wenting Du, Rolf A. Brekken · 2019 · Frontiers in Oncology
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