IRES unplugged
Open accessAbstract
Cap-independent translation by IRESs can occur from various locations in mRNA [Also see Research Article by Weingarten-Gabbay et al. ]
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The finding that cap-independent 5′ UTRs have poor translation rate is consistent with previous studies showing IRES are more efficient under stress conditions.
“Our results demonstrated that cap-independent 5′ UTRs exhibited a poor translation rate across three different cell lines compared to cap-dependent 5′ UTRs, which is consistent with previous studies showing that IRES are more efficient under stress conditions.42,43”
From Evaluation of synthetic mRNA with selected UTR sequences and alternative poly(A) tail, in vitro and in vivo (2025) · cites this paper as [43]
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Research works printed but not linked: 2
- R. J. Jackson,. Biochem Soc Trans. 33, 1231-1241 (2005)
- S. R. Thompson, Wiley Interdiscip Rev RNA. 3, 697-705 (2012)
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Medjmedj, A., Genon, H., Hezili, D., Loth, A. N., Clemençon, R., Guimpied, C., Mollet, L., Bigot, A., Wien, F., Hamacek, J., et al. (2025) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2025.102648 · Cited by 19 · see citing works
- Authors
- Gebauer, F., & Hentze, M. W.
- Affiliations
- Universitat Pompeu Fabra (ES)
- European Molecular Biology Laboratory (DE)
- Venue
- Science
- Published
- 2016-01-15
- Volume
- 351
- Issue
- 6270
- Pages
- 228-228
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2416172680
- Cited by
- 11
- References
- 0
- Citations by year
- 2025: 2 · 2023: 2 · 2021: 1 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- internal ribosome entry site, cap-independent translation, mRNA translation initiation, translation initiation sites
- MeSH terms
- Humans, RNA Caps, Protein Biosynthesis, Genome, Human, Genome, Viral
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