The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains
Open accessAbstract
Peptide domain links phosphate need to uptake: Cellular phosphate (Pi) levels are tightly controlled, but it is not clear how eukaryotic cells actually “measure” the concentration of Pi. Wild et al. now show that inositol polyphosphate (InsP) signaling molecules regulate Pi homeostasis in fungi, plants, and humans by interacting with SPX-domain-containing proteins. SPX domains are found in many eukaryotic Pi transporters, Pi-regulated enzymes, and signaling proteins. InsP binding allowed SPX domains to interact with different target proteins. In plants, one such target protein is a transcription factor. During normal growth, high levels of InsP promoted formation of a SPX protein-transcription factor complex. Under Pi starvation, InsP levels dropped, releasing the transcription factor to promote Pi starvation-response gene transcription. Science , this issue p. 986
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Coot : model-building tools for molecular graphics
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Phaser crystallographic software
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Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor
Sheard, L. B., Tan, X., Mao, H., Withers, J., Ben-Nissan, G., Hinds, T. R., Kobayashi, Y., Hsu, F.-F., Sharon, M., Browse, J., et al. (2010) · Nature · doi:10.1038/nature09430 · Cited by 1,497
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Ubiquitin ligases: structure, function, and regulation
Zheng, N., & Shabek, N. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014922 · Cited by 1,499
Potassium and phosphorus transport and signaling in plants
Wang, Y., Chen, Y., & Wu, W. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13053 · Cited by 431
The social and structural architecture of the yeast protein interactome
Michaelis, A. C., Brunner, A.-D., Zwiebel, M., Meier, F., Strauss, M. T., Bludau, I., & Mann, M. (2023) · Nature · doi:10.1038/s41586-023-06739-5 · Cited by 119
ITPK1 Mediates the Lipid-Independent Synthesis of Inositol Phosphates Controlled by Metabolism
Desfougères, Y., Wilson, M. S. C., Laha, D., Miller, G. J., & Saiardi, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911431116 · Cited by 93
Self-citationRenal phosphate handling and inherited disorders of phosphate reabsorption: an update
Wagner, C. A., Rubio-Aliaga, I., & Hernando, N. (2019) · Pediatric Nephrology · doi:10.1007/s00467-017-3873-3 · Cited by 73
Metadata
- Authors
- Wild, R., Gerasimaite, R., Jung, J.-Y., Truffault, V., Pavlovic, I., Schmidt, A., Saiardi, A., Jessen, H. J., Poirier, Y., Hothorn, M., & Mayer, A.
- Venue
- Science
- Published
- 2016-05-20
- Volume
- 352
- Issue
- 6288
- Pages
- 986-990
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2341849113
- Cited by
- 627
- References
- 4
- FWCI
- 51.31
- Type
- journal article
- Language
- en
- Open access
- green
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