The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Prostaglandin E 2 constrains systemic inflammation through an innate lymphoid cell–IL-22 axis
Open accessAbstract
A prostaglandin barrier to inflammation: Blood-borne bacterial infections and severe trauma can send the immune system into overdrive, causing it to pump out inflammatory mediators, sometimes at lethal doses. Duffin et al. now report on a role for prostaglandins in keeping systemic inflammation in check. Systemic inflammation correlates with decreased production of the prostaglandin E2 (PGE2). Blocking PGE2 signaling in mice led to severe inflammation associated with the translocation of gut bacteria. PGE2 acts on innate lymphoid cells, which produce interleukin-22, a secreted protein that helps promote intestinal integrity. Science , this issue p. 1333
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A network-based analysis of systemic inflammation in humans
Program, I. A. H. R. T. I. L. S. C. R., Calvano, S. E., Xiao, W., Richards, D. R., Felciano, R. M., Baker, H. V., Cho, R. J., Chen, R. O., Brownstein, B. H., Cobb, J. P., et al. (2005) · Nature · doi:10.1038/nature03985 · Cited by 1,429
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
Johansson, J. U., Pradhan, S., Lokteva, L. A., Woodling, N. S., Ko, N., Brown, H. D., Wang, Q., Loh, C., Cekanaviciute, E., Buckwalter, M., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2203-13.2013 · Cited by 96
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Design of therapeutic biomaterials to control inflammation
Tu, Z., Zhong, Y., Hu, H., Shao, D., Haag, R., Schirner, M., Lee, J., Sullenger, B., & Leong, K. W. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00426-z · Cited by 513
Innate lymphoid cells: major players in inflammatory diseases
Ebbo, M., Crinier, A., Vély, F., & Vivier, E. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.86 · Cited by 363
Prostaglandin‐cytokine crosstalk in chronic inflammation
Yao, C., & Narumiya, S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14530 · Cited by 283
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Metadata
- Authors
- Duffin, R., O’Connor, R. A., Crittenden, S., Forster, T., Yu, C., Zheng, X., Smyth, D., Robb, C. T., Rossi, F., Skouras, C., Tang, S., Richards, J., Pellicoro, A., Weller, R. B., Breyer, R. M., Mole, D. J., Iredale, J. P., Anderton, S. M., Narumiya, S., Maizels, R. M., Ghazal, P., Howie, S. E., Rossi, A. G., & Yao, C.
- Venue
- Science
- Published
- 2016-03-18
- Volume
- 351
- Issue
- 6279
- Pages
- 1333-1338
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2310510539
- Cited by
- 182
- References
- 5
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Duffin, R., O’Connor, R. A., Crittenden, S., Forster, T., Yu, C., Zheng, X., Smyth, D., Robb, C. T., Rossi, F., Skouras, C., Tang, S., Richards, J., Pellicoro, A., Weller, R. B., Breyer, R. M., Mole, D. J., Iredale, J. P., Anderton, S. M., Narumiya, S., . . . Yao, C. (2016). Prostaglandin E 2 constrains systemic inflammation through an innate lymphoid cell–IL-22 axis. Science. https://doi.org/10.1126/science.aad9903
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
