The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Open accessAbstract
Outsourcing cancer immunotherapy: Successful cancer immunotherapy depends on a patient's T cells recognizing tumor-specific mutations and then waging a lethal attack. Despite tumors harboring many mutations, most individuals have very few T cells that respond to these so-called “neo-antigens.” Strønen et al. isolated T cells from healthy donors that responded to predicted neo-antigens expressed by melanomas taken from three patients, sometimes including neo-antigens that the patient's own T cells ignored (see the Perspective by Yadav and Delamarre). Testing whether such an outsourcing strategy could improve clinical outcomes will be an important next step. Science , this issue p. 1337 ; see also p. 1275
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Universal Patterns of Selection in Cancer and Somatic Tissues
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Targeting neoantigens to augment antitumour immunity
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Metadata
- Authors
- Strønen, E., Toebes, M., Kelderman, S., van Buuren, M. M., Yang, W., van Rooij, N., Donia, M., Böschen, M.-L., Lund-Johansen, F., Olweus, J., & Schumacher, T. N.
- Venue
- Science
- Published
- 2016-06-10
- Volume
- 352
- Issue
- 6291
- Pages
- 1337-1341
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2404396229
- Cited by
- 445
- References
- 41
- FWCI
- 34.32
- Type
- journal article
- Language
- en
- Open access
- green
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