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The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril
Open accessAbstract
What's in a fold?: Bacterially secreted peptides known as PSMs (phenol-soluble modulins) stimulate inflammatory responses, lyse human cells, and contribute to biofilm structuring. PSMα3 is a virulent 22-residue amyloid peptide secreted by Staphylococcus aureus. Tayeb-Fligelman et al. present a high-resolution structure encompassing the full length of the amyloid's sequence. This structure reveals an unexpected departure from the common amyloid cross-β folded architecture. Instead, PSMα3 forms amphipathic α-helices that are folded to stack perpendicular to the fibril axis into sheets. This unusual cross-α structure was important for fibril toxicity. Science , this issue p. 831
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Metadata
- Authors
- Tayeb-Fligelman, E., Tabachnikov, O., Moshe, A., Goldshmidt-Tran, O., Sawaya, M. R., Coquelle, N., Colletier, J.-P., & Landau, M.
- Venue
- Science
- Published
- 2017-02-24
- Volume
- 355
- Issue
- 6327
- Pages
- 831-833
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2915521488
- Cited by
- 304
- References
- 66
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- green
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