Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase
Verba, Kliment A., Wang, Ray Yu-Ruei, Arakawa, Akihiko, Liu, Yanxin, Shirouzu, Mikako, Yokoyama, Shigeyuki, Agard, David A.·2016·Science
Cited by (431)
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- Additional file 5 of AUY922 induces retinal toxicity through attenuating TRPM1Shen, Che-Hung, Hsieh, Chi-Che, Jiang, Kuan-Ying, Lin, Chih-Yu, Chiang, Nai-Jung, Li, Ting-Wei, Yen, Chun-Ting, Chen, Wan-Ju, Hwang, Daw-Yang, LiTzong Chen · 2021 · Figshare
- Additional file 3 of AUY922 induces retinal toxicity through attenuating TRPM1Shen, Che-Hung, Hsieh, Chi-Che, Jiang, Kuan-Ying, Lin, Chih-Yu, Chiang, Nai-Jung, Li, Ting-Wei, Yen, Chun-Ting, Chen, Wan-Ju, Hwang, Daw-Yang, LiTzong Chen · 2021 · Figshare
- Additional file 6 of AUY922 induces retinal toxicity through attenuating TRPM1Shen, Che-Hung, Hsieh, Chi-Che, Jiang, Kuan-Ying, Lin, Chih-Yu, Chiang, Nai-Jung, Li, Ting-Wei, Yen, Chun-Ting, Chen, Wan-Ju, Hwang, Daw-Yang, LiTzong Chen · 2021 · Figshare
- Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complexKei Okatsu, H Yamamoto, Akinori Okamoto, Simon Goto, Yumiko Nishimoto, Yukihiko Sugita, Takeshi Noda, Shuya Fukai · 2026 · eLife
- Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complexKei Okatsu, H Yamamoto, Akinori Okamoto, Simon Goto, Yumiko Nishimoto, Yukihiko Sugita, Takeshi Noda, Shuya Fukai · 2026 · eLife
- Comparative analysis of the impact of Heat shock protein 90 kDa or Cdc37 mutation on the yeast proteomeErick I. Rios, Jill L. Johnson · 2026 · Cell Stress and Chaperones
- Etude des principes d’assemblage et de maturation des kinases de la famille des PIKKs chez Schizosaccharomyces pombeDamien Toullec · 2020 · theses.fr (ABES)
- Etude moléculaire des étapes initiales d'importation de protéines mitochondrialesIva Sučec · 2022
- L'interaction Hsp90/co-chaperonnes : nouvelle cible pour le traitement des candidoses invasivesCélia Rouges · 2023
- HSP90 une cible thérapeutique dynamique : modulation des conformations peuplées par la liaison de ligandsFaustine Henot · 2022
- MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase SeparationYanshen Zhang, Weiya Xu, Wenxiu Duan, Yu Wei, Wenli Jiang, Feng Zhu, Chengdong Huang, Chao Wang, Yihui Bi · 2026 · eLife
- Eupalinolide B Ameliorates Diabetic Kidney Disease via Inhibition of Cell Division Cycle 37–Mediated Inflammatory PathwaysHuiying Li, Guanjun Li, Ling Huang, Tianyun Fan, Ying Zhang, Junzhe Zhang, Liwei Gu, Jianyou Wang, Li Hu, Hui Tang et al. · 2026 · Journal of the American Society of Nephrology
- The structure of the apo-PIWI HSP90 complexPeter Donlon, Paula Sotelo‐Parrilla, David MacKenzie MacLeod, Aleksandra Rosińska, Tamoghna Chowdhury, Katherine Isabella Leith, Ansgar Zoch, Christos Spanos, Atlanta G. Cook, Arockia Jeyaprakash Arulanandam et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Post-Translational Modification as an Allosteric Switch in Hsp90: How Dual Phosphorylation Locks Chaperone Complexes into Hyperstabilized StatesGiorgio Bonollo, Benedetto Roncati, Luca Torielli, Shujuan Wang, Chiranjeevi Pasala, Silvia Pavoni, Francesco Frigerio, Fabrizio Cinquini, Gabriela Chiosis, Stefano Artin Serapian et al. · 2026 · The Journal of Physical Chemistry Letters
- Chaperones in kinase homeostasis and drug discoveryCaiyiren Wen, Qidong You, Lei Wang · 2026 · Trends in Pharmacological Sciences
- Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast CancerJaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič · 2026 · Medicinal Research Reviews
- Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus ComplexQingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun · 2026 · Advanced Science
- Electron Paramagnetic Resonance (EPR) Spectroscopy Reveals Nucleotide- and Partner-Dependent Conformational Ensembles in Hsp90Christini Fiotaki, Daniella Goldfarb, Angeliki Giannouli · 2026 · Journal of Physical Chemistry B
- Pathway-scale variant effect mapping reveals the importance of cell contextJessica J. Simon, Sriram Pendyala, A.Felicia Adebanjo, Daniel L. Holmes, Madeline Walsh, Allyssa J. Vandi, Ziyu R. Wang, Melinda K. Wheelock, Jordan L. Opsahl, Aman Shihora et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Hsp90 as a master regulator in autoimmunity: from cellular stress to clinical opportunityScott A. Scarneo, Robert Freeze, Timothy AJ Haystead · 2026 · Open Biology
- BindingDB Entry 50006781: Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50013045: Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50009294: Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50006714: C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of action.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50018162: Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50016614: Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50019179: Targeted Protein Degradation Induced by HEMTACs Based on HSP90.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50008550: Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.BindingDB · 2021 · UC San Diego