Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

Verba, Kliment A., Wang, Ray Yu-Ruei, Arakawa, Akihiko, Liu, Yanxin, Shirouzu, Mikako, Yokoyama, Shigeyuki, Agard, David A.·2016·Science

Cited by (431)

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  4. Additional file 5 of AUY922 induces retinal toxicity through attenuating TRPM1
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  6. Additional file 6 of AUY922 induces retinal toxicity through attenuating TRPM1
    Shen, Che-Hung, Hsieh, Chi-Che, Jiang, Kuan-Ying, Lin, Chih-Yu, Chiang, Nai-Jung, Li, Ting-Wei, Yen, Chun-Ting, Chen, Wan-Ju, Hwang, Daw-Yang, LiTzong Chen · 2021 · Figshare
  7. Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex
    Kei Okatsu, H Yamamoto, Akinori Okamoto, Simon Goto, Yumiko Nishimoto, Yukihiko Sugita, Takeshi Noda, Shuya Fukai · 2026 · eLife
  8. Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex
    Kei Okatsu, H Yamamoto, Akinori Okamoto, Simon Goto, Yumiko Nishimoto, Yukihiko Sugita, Takeshi Noda, Shuya Fukai · 2026 · eLife
  9. Comparative analysis of the impact of Heat shock protein 90 kDa or Cdc37 mutation on the yeast proteome
    Erick I. Rios, Jill L. Johnson · 2026 · Cell Stress and Chaperones
  10. Etude des principes d’assemblage et de maturation des kinases de la famille des PIKKs chez Schizosaccharomyces pombe
    Damien Toullec · 2020 · theses.fr (ABES)
  11. Etude moléculaire des étapes initiales d'importation de protéines mitochondriales
    Iva Sučec · 2022
  12. L'interaction Hsp90/co-chaperonnes : nouvelle cible pour le traitement des candidoses invasives
    Célia Rouges · 2023
  13. HSP90 une cible thérapeutique dynamique : modulation des conformations peuplées par la liaison de ligands
    Faustine Henot · 2022
  14. MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase Separation
    Yanshen Zhang, Weiya Xu, Wenxiu Duan, Yu Wei, Wenli Jiang, Feng Zhu, Chengdong Huang, Chao Wang, Yihui Bi · 2026 · eLife
  15. Eupalinolide B Ameliorates Diabetic Kidney Disease via Inhibition of Cell Division Cycle 37–Mediated Inflammatory Pathways
    Huiying Li, Guanjun Li, Ling Huang, Tianyun Fan, Ying Zhang, Junzhe Zhang, Liwei Gu, Jianyou Wang, Li Hu, Hui Tang et al. · 2026 · Journal of the American Society of Nephrology
  16. The structure of the apo-PIWI HSP90 complex
    Peter Donlon, Paula Sotelo‐Parrilla, David MacKenzie MacLeod, Aleksandra Rosińska, Tamoghna Chowdhury, Katherine Isabella Leith, Ansgar Zoch, Christos Spanos, Atlanta G. Cook, Arockia Jeyaprakash Arulanandam et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Post-Translational Modification as an Allosteric Switch in Hsp90: How Dual Phosphorylation Locks Chaperone Complexes into Hyperstabilized States
    Giorgio Bonollo, Benedetto Roncati, Luca Torielli, Shujuan Wang, Chiranjeevi Pasala, Silvia Pavoni, Francesco Frigerio, Fabrizio Cinquini, Gabriela Chiosis, Stefano Artin Serapian et al. · 2026 · The Journal of Physical Chemistry Letters
  18. Chaperones in kinase homeostasis and drug discovery
    Caiyiren Wen, Qidong You, Lei Wang · 2026 · Trends in Pharmacological Sciences
  19. Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
    Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič · 2026 · Medicinal Research Reviews
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  21. Electron Paramagnetic Resonance (EPR) Spectroscopy Reveals Nucleotide- and Partner-Dependent Conformational Ensembles in Hsp90
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    Jessica J. Simon, Sriram Pendyala, A.Felicia Adebanjo, Daniel L. Holmes, Madeline Walsh, Allyssa J. Vandi, Ziyu R. Wang, Melinda K. Wheelock, Jordan L. Opsahl, Aman Shihora et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Hsp90 as a master regulator in autoimmunity: from cellular stress to clinical opportunity
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  24. BindingDB Entry 50006781: Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design.
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  25. BindingDB Entry 50013045: Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.
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  26. BindingDB Entry 50009294: Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.
    BindingDB · 2021 · UC San Diego
  27. BindingDB Entry 50006714: C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of action.
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  28. BindingDB Entry 50018162: Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1.
    BindingDB · 2024 · UC San Diego
  29. BindingDB Entry 50016614: Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
    BindingDB · 2023 · UC San Diego
  30. BindingDB Entry 50019179: Targeted Protein Degradation Induced by HEMTACs Based on HSP90.
    BindingDB · 2024 · UC San Diego
  31. BindingDB Entry 50008550: Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.
    BindingDB · 2021 · UC San Diego