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Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment
Abstract
The ability to express heterologous proteins in plants has led to the concept of using plants as “bioreactors” or “biofactories” for the production of pharmaceutical proteins. Although initial studies were promising, the pathway to commercialization and deployment in a clinical setting has proven to be a somewhat rocky road. This Review examines the technical developments that have led to the current increase in interest in the use of plants for the production of pharmaceutical proteins, particularly in the context of clinical trials.
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Cited by
Progress in biopharmaceutical development
Kesik‐Brodacka, M. (2018) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1617 · Cited by 353
Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine
Marsian, J., Fox, H., Bahar, M. W., Kotecha, A., Fry, E. E., Stuart, D. I., Macadam, A. J., Rowlands, D. J., & Lomonossoff, G. P. (2017) · Nature Communications · doi:10.1038/s41467-017-00090-w · Cited by 121
Self-citationCurrent advances in the algae-made biopharmaceuticals field
Rosales-Mendoza, S., Solís-Andrade, K. I., Márquez-Escobar, V. A., González-Ortega, O., & Bañuelos-Hernandez, B. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1739643 · Cited by 55
Metadata
- Authors
- Lomonossoff, G. P., & D’Aoust, M.-A.
- Venue
- Science
- Published
- 2016-09-16
- Volume
- 353
- Issue
- 6305
- Pages
- 1237-1240
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2520255402
- Cited by
- 194
- References
- 0
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
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