The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Copper-catalyzed asymmetric addition of olefin-derived nucleophiles to ketones
Open accessAbstract
Olefins enlisted to attack ketones: The reaction of C=O groups in ketones with organometallic compounds is a common method to form carbon-carbon bonds. One drawback to this approach, however, is that the organometallics, such as magnesium-derived Grignard reagents, are difficult to handle and susceptible to side reactions. Yang et al. present an alternative method, whereby a copper catalyst activates stable olefins (C=C double bonds) to attack ketones at room temperature. An added silane functions as a reducing agent, and a chiral phosphine ligand renders the reaction highly enantioselective. Science , this issue p. 144
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Noyori, R., & Kitamura, M. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199100491 · Cited by 1,214
Cited by
The Construction and Application of C=S Bonds
Murai, T. (2018) · Topics in Current Chemistry · doi:10.1007/s41061-018-0209-0 · Cited by 36
Metadata
- Authors
- Yang, Y., Perry, I. B., Lu, G., Liu, P., & Buchwald, S. L.
- Venue
- Science
- Published
- 2016-07-08
- Volume
- 353
- Issue
- 6295
- Pages
- 144-150
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2409674287
- Cited by
- 294
- References
- 1
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, Y., Perry, I. B., Lu, G., Liu, P., & Buchwald, S. L. (2016). Copper-catalyzed asymmetric addition of olefin-derived nucleophiles to ketones. Science. https://doi.org/10.1126/science.aaf7720
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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